| Fr., 07.04.2000 | FSV Mainz 05 - FC St. Pauli | 1:1 |
| Fr., 07.04.2000 | 1. FC Nürnberg - Alemannia Aachen | 3:1 |
| Fr., 07.04.2000 | Hannover 96 - FC Energie Cottbus | 3:2 |
| Sa., 08.04.2000 | Borussia Mönchengladbach - Stuttgarter Kickers | 1:1 |
| So., 09.04.2000 | SC Fortuna Köln - 1. FC Köln | 4:1 |
| So., 09.04.2000 | Chemnitzer FC - Karlsruher SC | 3:1 |
| So., 09.04.2000 | SV Waldhof Mannheim - SpVgg Greuther Fürth | 3:3 |
| So., 09.04.2000 | Kickers Offenbach - Rot-Weiß Oberhausen | 2:1 |
| Mo., 10.04.2000 | Tennis Borussia Berlin - VfL Bochum | 0:4 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | 1. FC Köln | 26 | 14-7-5 | 50:26 | 24 | 49 |
| 2. | |  | VfL Bochum | 26 | 14-5-7 | 45:34 | 11 | 47 |
| 3. |  |  | 1. FC Nürnberg | 26 | 12-7-7 | 43:39 | 4 | 43 |
| 4. |  |  | FC Energie Cottbus | 26 | 13-3-10 | 48:33 | 15 | 42 |
| 5. | |  | Borussia Mönchengladbach | 26 | 10-10-6 | 41:31 | 10 | 40 |
| 6. | |  | Alemannia Aachen | 26 | 10-9-7 | 36:40 | -4 | 39 |
| 7. | |  | Tennis Borussia Berlin | 26 | 9-10-7 | 33:33 | 0 | 37 |
| 8. | |  | SV Waldhof Mannheim | 26 | 8-12-6 | 38:36 | 2 | 36 |
| 9. | |  | Hannover 96 | 26 | 9-7-10 | 39:40 | -1 | 34 |
| 10. | |  | FSV Mainz 05 | 26 | 7-11-8 | 32:31 | 1 | 32 |
| 11. | |  | Chemnitzer FC | 26 | 8-8-10 | 34:37 | -3 | 32 |
| 12. | |  | Rot-Weiß Oberhausen | 26 | 7-10-9 | 27:30 | -3 | 31 |
| 13. | |  | SpVgg Greuther Fürth | 26 | 6-13-7 | 28:32 | -4 | 31 |
| 14. | |  | FC St. Pauli | 26 | 6-12-8 | 26:31 | -5 | 30 |
| 15. | |  | Kickers Offenbach | 26 | 6-10-10 | 26:37 | -11 | 28 |
| 16. | |  | SC Fortuna Köln | 26 | 5-11-10 | 25:35 | -10 | 26 |
| 17. | |  | Stuttgarter Kickers | 26 | 6-7-13 | 36:49 | -13 | 25 |
| 18. | |  | Karlsruher SC | 26 | 3-10-13 | 29:42 | -13 | 19 |