| Sa., 15.11.1980 | HFC Chemie - FC Karl-Marx-Stadt | 4:1 |
| Sa., 15.11.1980 | FC Vorwärts Frankfurt/O. - 1. FC Magdeburg | 1:2 |
| Sa., 15.11.1980 | 1. FC Lok Leipzig - BSG Wismut Aue | 6:1 |
| Sa., 15.11.1980 | BSG Sachsenring Zwickau - FC Rot-Weiß Erfurt | 2:0 |
| Sa., 15.11.1980 | FC Carl Zeiss Jena - FC Hansa Rostock | 1:0 |
| Sa., 15.11.1980 | BSG Stahl Riesa - BSG Chemie Böhlen | 4:0 |
| Sa., 15.11.1980 | BFC Dynamo - SG Dynamo Dresden | 2:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | 1. FC Magdeburg | 11 | 9-1-1 | 28:9 | 19 | 19 - 3 |
| 2. |  |  | BFC Dynamo | 11 | 8-2-1 | 33:9 | 24 | 18 - 4 |
| 3. |  |  | SG Dynamo Dresden | 11 | 8-1-2 | 21:12 | 9 | 17 - 5 |
| 4. | |  | FC Carl Zeiss Jena | 11 | 8-0-3 | 27:15 | 12 | 16 - 6 |
| 5. | |  | 1. FC Lok Leipzig | 11 | 6-1-4 | 28:16 | 12 | 13 - 9 |
| 6. | |  | FC Hansa Rostock | 11 | 3-4-4 | 15:16 | -1 | 10 - 12 |
| 7. | |  | BSG Chemie Böhlen | 11 | 4-2-5 | 11:17 | -6 | 10 - 12 |
| 8. | |  | FC Vorwärts Frankfurt/O. | 11 | 3-3-5 | 21:24 | -3 | 9 - 13 |
| 9. | |  | FC Rot-Weiß Erfurt | 11 | 4-1-6 | 13:24 | -11 | 9 - 13 |
| 10. | |  | HFC Chemie | 11 | 4-0-7 | 19:22 | -3 | 8 - 14 |
| 11. | |  | FC Karl-Marx-Stadt | 11 | 2-4-5 | 15:22 | -7 | 8 - 14 |
| 12. | |  | BSG Wismut Aue | 11 | 3-2-6 | 11:25 | -14 | 8 - 14 |
| 13. | |  | BSG Stahl Riesa | 11 | 1-4-6 | 17:30 | -13 | 6 - 16 |
| 14. | |  | BSG Sachsenring Zwickau | 11 | 1-1-9 | 9:27 | -18 | 3 - 19 |