| Sa., 11.04.1981 | 1. FC Magdeburg - FC Carl Zeiss Jena | 3:1 |
| Sa., 11.04.1981 | FC Vorwärts Frankfurt/O. - HFC Chemie | 1:0 |
| Sa., 11.04.1981 | 1. FC Lok Leipzig - BSG Sachsenring Zwickau | 0:0 |
| Sa., 11.04.1981 | FC Karl-Marx-Stadt - BSG Chemie Böhlen | 2:1 |
| Sa., 11.04.1981 | FC Rot-Weiß Erfurt - BFC Dynamo | 3:3 |
| Sa., 11.04.1981 | BSG Wismut Aue - BSG Stahl Riesa | 2:3 |
| Sa., 11.04.1981 | SG Dynamo Dresden - FC Hansa Rostock | 4:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 20 | 13-4-3 | 56:22 | 34 | 30 - 10 |
| 2. |  |  | 1. FC Magdeburg | 20 | 13-2-5 | 47:26 | 21 | 28 - 12 |
| 3. | |  | SG Dynamo Dresden | 20 | 13-2-5 | 40:27 | 13 | 28 - 12 |
| 4. |  |  | FC Carl Zeiss Jena | 20 | 12-3-5 | 43:25 | 18 | 27 - 13 |
| 5. | |  | FC Vorwärts Frankfurt/O. | 20 | 9-5-6 | 43:32 | 11 | 23 - 17 |
| 6. | |  | FC Rot-Weiß Erfurt | 20 | 7-6-7 | 29:39 | -10 | 20 - 20 |
| 7. | |  | 1. FC Lok Leipzig | 20 | 8-3-9 | 34:25 | 9 | 19 - 21 |
| 8. | |  | HFC Chemie | 20 | 9-1-10 | 32:30 | 2 | 19 - 21 |
| 9. | |  | FC Hansa Rostock | 20 | 6-6-8 | 26:32 | -6 | 18 - 22 |
| 10. | |  | FC Karl-Marx-Stadt | 20 | 4-8-8 | 24:36 | -12 | 16 - 24 |
| 11. | |  | BSG Chemie Böhlen | 20 | 5-4-11 | 20:37 | -17 | 14 - 26 |
| 12. | |  | BSG Wismut Aue | 20 | 5-4-11 | 25:46 | -21 | 14 - 26 |
| 13. | |  | BSG Sachsenring Zwickau | 20 | 4-4-12 | 22:41 | -19 | 12 - 28 |
| 14. | |  | BSG Stahl Riesa | 20 | 4-4-12 | 29:52 | -23 | 12 - 28 |