| Sa., 22.11.1980 | FC Karl-Marx-Stadt - BSG Sachsenring Zwickau | 1:1 |
| Sa., 22.11.1980 | BFC Dynamo - BSG Stahl Riesa | 4:1 |
| Sa., 22.11.1980 | BSG Chemie Böhlen - FC Carl Zeiss Jena | 1:3 |
| Sa., 22.11.1980 | FC Hansa Rostock - HFC Chemie | 1:1 |
| Sa., 22.11.1980 | FC Rot-Weiß Erfurt - 1. FC Lok Leipzig | 1:0 |
| Sa., 22.11.1980 | BSG Wismut Aue - FC Vorwärts Frankfurt/O. | 1:1 |
| Sa., 22.11.1980 | SG Dynamo Dresden - 1. FC Magdeburg | 3:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 12 | 9-2-1 | 37:10 | 27 | 20 - 4 |
| 2. |  |  | 1. FC Magdeburg | 12 | 9-1-2 | 29:12 | 17 | 19 - 5 |
| 3. |  |  | SG Dynamo Dresden | 12 | 9-1-2 | 24:13 | 11 | 19 - 5 |
| 4. | |  | FC Carl Zeiss Jena | 12 | 9-0-3 | 30:16 | 14 | 18 - 6 |
| 5. | |  | 1. FC Lok Leipzig | 12 | 6-1-5 | 28:17 | 11 | 13 - 11 |
| 6. | |  | FC Hansa Rostock | 12 | 3-5-4 | 16:17 | -1 | 11 - 13 |
| 7. | |  | FC Rot-Weiß Erfurt | 12 | 5-1-6 | 14:24 | -10 | 11 - 13 |
| 8. | |  | FC Vorwärts Frankfurt/O. | 12 | 3-4-5 | 22:25 | -3 | 10 - 14 |
| 9. | |  | BSG Chemie Böhlen | 12 | 4-2-6 | 12:20 | -8 | 10 - 14 |
| 10. | |  | HFC Chemie | 12 | 4-1-7 | 20:23 | -3 | 9 - 15 |
| 11. | |  | FC Karl-Marx-Stadt | 12 | 2-5-5 | 16:23 | -7 | 9 - 15 |
| 12. | |  | BSG Wismut Aue | 12 | 3-3-6 | 12:26 | -14 | 9 - 15 |
| 13. | |  | BSG Stahl Riesa | 12 | 1-4-7 | 18:34 | -16 | 6 - 18 |
| 14. | |  | BSG Sachsenring Zwickau | 12 | 1-2-9 | 10:28 | -18 | 4 - 20 |