| Sa., 29.11.1980 | 1. FC Magdeburg - BSG Wismut Aue | 4:1 |
| Sa., 29.11.1980 | FC Vorwärts Frankfurt/O. - FC Rot-Weiß Erfurt | 4:1 |
| Sa., 29.11.1980 | 1. FC Lok Leipzig - FC Karl-Marx-Stadt | 3:1 |
| Sa., 29.11.1980 | BSG Sachsenring Zwickau - FC Hansa Rostock | 2:0 |
| Sa., 29.11.1980 | HFC Chemie - BSG Chemie Böhlen | 2:0 |
| Sa., 29.11.1980 | FC Carl Zeiss Jena - BFC Dynamo | 2:2 |
| Sa., 29.11.1980 | BSG Stahl Riesa - SG Dynamo Dresden | 0:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 13 | 9-3-1 | 39:12 | 27 | 21 - 5 |
| 2. | |  | 1. FC Magdeburg | 13 | 10-1-2 | 33:13 | 20 | 21 - 5 |
| 3. | |  | SG Dynamo Dresden | 13 | 10-1-2 | 26:13 | 13 | 21 - 5 |
| 4. | |  | FC Carl Zeiss Jena | 13 | 9-1-3 | 32:18 | 14 | 19 - 7 |
| 5. | |  | 1. FC Lok Leipzig | 13 | 7-1-5 | 31:18 | 13 | 15 - 11 |
| 6. |  |  | FC Vorwärts Frankfurt/O. | 13 | 4-4-5 | 26:26 | 0 | 12 - 14 |
| 7. | |  | HFC Chemie | 13 | 5-1-7 | 22:23 | -1 | 11 - 15 |
| 8. |  |  | FC Hansa Rostock | 13 | 3-5-5 | 16:19 | -3 | 11 - 15 |
| 9. | |  | FC Rot-Weiß Erfurt | 13 | 5-1-7 | 15:28 | -13 | 11 - 15 |
| 10. | |  | BSG Chemie Böhlen | 13 | 4-2-7 | 12:22 | -10 | 10 - 16 |
| 11. | |  | FC Karl-Marx-Stadt | 13 | 2-5-6 | 17:26 | -9 | 9 - 17 |
| 12. | |  | BSG Wismut Aue | 13 | 3-3-7 | 13:30 | -17 | 9 - 17 |
| 13. | |  | BSG Sachsenring Zwickau | 13 | 2-2-9 | 12:28 | -16 | 6 - 20 |
| 14. | |  | BSG Stahl Riesa | 13 | 1-4-8 | 18:36 | -18 | 6 - 20 |