| Sa., 21.02.1981 | 1. FC Magdeburg - FC Rot-Weiß Erfurt | 1:2 |
| Sa., 21.02.1981 | FC Vorwärts Frankfurt/O. - FC Karl-Marx-Stadt | 4:1 |
| Sa., 21.02.1981 | 1. FC Lok Leipzig - FC Hansa Rostock | 1:2 |
| Sa., 21.02.1981 | BSG Sachsenring Zwickau - BSG Chemie Böhlen | 2:2 |
| Sa., 21.02.1981 | HFC Chemie - BFC Dynamo | 2:1 |
| Sa., 21.02.1981 | FC Carl Zeiss Jena - BSG Stahl Riesa | 1:0 |
| Sa., 21.02.1981 | BSG Wismut Aue - SG Dynamo Dresden | 3:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 14 | 9-3-2 | 40:14 | 26 | 21 - 7 |
| 2. | |  | 1. FC Magdeburg | 14 | 10-1-3 | 34:15 | 19 | 21 - 7 |
| 3. |  |  | FC Carl Zeiss Jena | 14 | 10-1-3 | 33:18 | 15 | 21 - 7 |
| 4. |  |  | SG Dynamo Dresden | 14 | 10-1-3 | 27:16 | 11 | 21 - 7 |
| 5. | |  | 1. FC Lok Leipzig | 14 | 7-1-6 | 32:20 | 12 | 15 - 13 |
| 6. | |  | FC Vorwärts Frankfurt/O. | 14 | 5-4-5 | 30:27 | 3 | 14 - 14 |
| 7. | |  | HFC Chemie | 14 | 6-1-7 | 24:24 | 0 | 13 - 15 |
| 8. | |  | FC Hansa Rostock | 14 | 4-5-5 | 18:20 | -2 | 13 - 15 |
| 9. | |  | FC Rot-Weiß Erfurt | 14 | 6-1-7 | 17:29 | -12 | 13 - 15 |
| 10. | |  | BSG Chemie Böhlen | 14 | 4-3-7 | 14:24 | -10 | 11 - 17 |
| 11. | |  | BSG Wismut Aue | 14 | 4-3-7 | 16:31 | -15 | 11 - 17 |
| 12. | |  | FC Karl-Marx-Stadt | 14 | 2-5-7 | 18:30 | -12 | 9 - 19 |
| 13. | |  | BSG Sachsenring Zwickau | 14 | 2-3-9 | 14:30 | -16 | 7 - 21 |
| 14. | |  | BSG Stahl Riesa | 14 | 1-4-9 | 18:37 | -19 | 6 - 22 |