| Sa., 21.03.1981 | 1. FC Magdeburg - BFC Dynamo | 2:4 |
| Sa., 21.03.1981 | FC Vorwärts Frankfurt/O. - BSG Stahl Riesa | 5:2 |
| Sa., 21.03.1981 | 1. FC Lok Leipzig - FC Carl Zeiss Jena | 0:0 |
| Sa., 21.03.1981 | BSG Sachsenring Zwickau - HFC Chemie | 0:3 |
| Sa., 21.03.1981 | FC Rot-Weiß Erfurt - FC Hansa Rostock | 3:1 |
| Sa., 21.03.1981 | BSG Wismut Aue - BSG Chemie Böhlen | 3:0 |
| Sa., 21.03.1981 | SG Dynamo Dresden - FC Karl-Marx-Stadt | 2:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 18 | 12-3-3 | 48:18 | 30 | 27 - 9 |
| 2. |  |  | 1. FC Magdeburg | 18 | 12-2-4 | 43:23 | 20 | 26 - 10 |
| 3. |  |  | FC Carl Zeiss Jena | 18 | 12-2-4 | 41:21 | 20 | 26 - 10 |
| 4. | |  | SG Dynamo Dresden | 18 | 12-2-4 | 36:24 | 12 | 26 - 10 |
| 5. | |  | FC Vorwärts Frankfurt/O. | 18 | 8-4-6 | 41:31 | 10 | 20 - 16 |
| 6. | |  | 1. FC Lok Leipzig | 18 | 8-2-8 | 34:24 | 10 | 18 - 18 |
| 7. | |  | FC Rot-Weiß Erfurt | 18 | 7-4-7 | 25:35 | -10 | 18 - 18 |
| 8. | |  | HFC Chemie | 18 | 8-1-9 | 31:29 | 2 | 17 - 19 |
| 9. | |  | FC Hansa Rostock | 18 | 6-5-7 | 25:27 | -2 | 17 - 19 |
| 10. | |  | BSG Wismut Aue | 18 | 5-4-9 | 22:38 | -16 | 14 - 22 |
| 11. | |  | FC Karl-Marx-Stadt | 18 | 3-7-8 | 21:34 | -13 | 13 - 23 |
| 12. | |  | BSG Chemie Böhlen | 18 | 5-3-10 | 18:34 | -16 | 13 - 23 |
| 13. | |  | BSG Sachsenring Zwickau | 18 | 3-3-12 | 19:41 | -22 | 9 - 27 |
| 14. | |  | BSG Stahl Riesa | 18 | 2-4-12 | 24:49 | -25 | 8 - 28 |