| Sa., 25.04.1981 | 1. FC Magdeburg - BSG Sachsenring Zwickau | 3:2 |
| Sa., 25.04.1981 | FC Vorwärts Frankfurt/O. - 1. FC Lok Leipzig | 1:2 |
| Sa., 25.04.1981 | FC Hansa Rostock - BFC Dynamo | 4:4 |
| Sa., 25.04.1981 | FC Karl-Marx-Stadt - BSG Stahl Riesa | 5:4 |
| Sa., 25.04.1981 | FC Rot-Weiß Erfurt - FC Carl Zeiss Jena | 0:0 |
| Sa., 25.04.1981 | BSG Wismut Aue - HFC Chemie | 4:1 |
| Sa., 25.04.1981 | SG Dynamo Dresden - BSG Chemie Böhlen | 2:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 22 | 14-5-3 | 65:26 | 39 | 33 - 11 |
| 2. | |  | 1. FC Magdeburg | 22 | 14-3-5 | 51:29 | 22 | 31 - 13 |
| 3. | |  | FC Carl Zeiss Jena | 22 | 13-4-5 | 45:25 | 20 | 30 - 14 |
| 4. | |  | SG Dynamo Dresden | 22 | 14-2-6 | 43:30 | 13 | 30 - 14 |
| 5. | |  | FC Vorwärts Frankfurt/O. | 22 | 10-5-7 | 46:34 | 12 | 25 - 19 |
| 6. |  |  | 1. FC Lok Leipzig | 22 | 10-3-9 | 38:27 | 11 | 23 - 21 |
| 7. |  |  | FC Rot-Weiß Erfurt | 22 | 8-7-7 | 30:39 | -9 | 23 - 21 |
| 8. | |  | HFC Chemie | 22 | 9-2-11 | 34:35 | -1 | 20 - 24 |
| 9. | |  | FC Hansa Rostock | 22 | 6-8-8 | 32:38 | -6 | 20 - 24 |
| 10. | |  | FC Karl-Marx-Stadt | 22 | 5-8-9 | 29:45 | -16 | 18 - 26 |
| 11. | |  | BSG Wismut Aue | 22 | 6-4-12 | 29:49 | -20 | 16 - 28 |
| 12. | |  | BSG Chemie Böhlen | 22 | 5-5-12 | 23:41 | -18 | 15 - 29 |
| 13. | |  | BSG Sachsenring Zwickau | 22 | 4-4-14 | 24:46 | -22 | 12 - 32 |
| 14. | |  | BSG Stahl Riesa | 22 | 4-4-14 | 33:58 | -25 | 12 - 32 |