| Sa., 25.10.1980 | 1. FC Lok Leipzig - FC Vorwärts Frankfurt/O. | 6:1 |
| Sa., 25.10.1980 | BSG Sachsenring Zwickau - 1. FC Magdeburg | 0:1 |
| Sa., 25.10.1980 | HFC Chemie - BSG Wismut Aue | 2:1 |
| Sa., 25.10.1980 | FC Carl Zeiss Jena - FC Rot-Weiß Erfurt | 1:2 |
| Sa., 25.10.1980 | BSG Stahl Riesa - FC Karl-Marx-Stadt | 3:3 |
| Sa., 25.10.1980 | BFC Dynamo - FC Hansa Rostock | 4:0 |
| Sa., 25.10.1980 | BSG Chemie Böhlen - SG Dynamo Dresden | 0:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 9 | 7-1-1 | 29:6 | 23 | 15 - 3 |
| 2. | |  | 1. FC Magdeburg | 9 | 7-1-1 | 22:7 | 15 | 15 - 3 |
| 3. | |  | SG Dynamo Dresden | 9 | 7-1-1 | 17:9 | 8 | 15 - 3 |
| 4. |  |  | FC Carl Zeiss Jena | 9 | 7-0-2 | 24:12 | 12 | 14 - 4 |
| 5. | |  | 1. FC Lok Leipzig | 9 | 5-1-3 | 21:11 | 10 | 11 - 7 |
| 6. | |  | FC Vorwärts Frankfurt/O. | 9 | 3-3-3 | 19:19 | 0 | 9 - 9 |
| 7. |  |  | BSG Chemie Böhlen | 9 | 4-1-4 | 9:11 | -2 | 9 - 9 |
| 8. | |  | FC Hansa Rostock | 9 | 2-4-3 | 9:13 | -4 | 8 - 10 |
| 9. | |  | FC Rot-Weiß Erfurt | 9 | 3-1-5 | 12:22 | -10 | 7 - 11 |
| 10. | |  | HFC Chemie | 9 | 3-0-6 | 15:20 | -5 | 6 - 12 |
| 11. | |  | FC Karl-Marx-Stadt | 9 | 1-4-4 | 11:16 | -5 | 6 - 12 |
| 12. | |  | BSG Wismut Aue | 9 | 2-2-5 | 8:18 | -10 | 6 - 12 |
| 13. | |  | BSG Stahl Riesa | 9 | 0-4-5 | 11:24 | -13 | 4 - 14 |
| 14. | |  | BSG Sachsenring Zwickau | 9 | 0-1-8 | 6:25 | -19 | 1 - 17 |