| Fr., 10.09.2021 | FSV Optik Rathenow - Hertha BSC Berlin II | 2:2 |
| Fr., 10.09.2021 | VSG Altglienicke - FC Eilenburg | 6:0 |
| Sa., 11.09.2021 | FC Carl Zeiss Jena - SV Lichtenberg 47 | 3:0 |
| So., 12.09.2021 | BFC Dynamo - BSG Chemie Leipzig | 2:0 |
| So., 12.09.2021 | Berliner AK 07 - VfB Germania Halberstadt | 4:2 |
| So., 12.09.2021 | FSV Union Fürstenwalde - ZFC Meuselwitz | 2:1 |
| Mi., 29.09.2021 | FSV 63 Luckenwalde - Chemnitzer FC | 1:1 |
| Mi., 13.10.2021 | VfB Auerbach - SV Babelsberg 03 | 2:3 |
| Mi., 03.11.2021 | Tennis Borussia Berlin - SV Tasmania Berlin | 0:0 |
| Mi., 10.11.2021 | 1. FC Lok Leipzig - FC Energie Cottbus | 1:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 10 | 9-0-1 | 27:9 | 18 | 27 |
| 2. |  |  | Berliner AK 07 | 10 | 7-1-2 | 17:10 | 7 | 22 |
| 3. | |  | VSG Altglienicke | 10 | 6-3-1 | 23:10 | 13 | 21 |
| 4. |  |  | FSV 63 Luckenwalde | 9 | 6-2-1 | 21:6 | 15 | 20 |
| 5. | |  | FC Carl Zeiss Jena | 9 | 6-1-2 | 19:6 | 13 | 19 |
| 6. | |  | VfB Germania Halberstadt | 9 | 5-0-4 | 20:15 | 5 | 15 |
| 7. | |  | BSG Chemie Leipzig | 10 | 4-2-4 | 10:10 | 0 | 14 |
| 8. | |  | FC Energie Cottbus | 7 | 4-1-2 | 17:7 | 10 | 13 |
| 9. | |  | SV Babelsberg 03 | 8 | 4-1-3 | 8:8 | 0 | 13 |
| 10. | |  | Hertha BSC Berlin II | 9 | 3-3-3 | 10:13 | -3 | 12 |
| 11. | |  | Chemnitzer FC | 8 | 3-2-3 | 9:8 | 1 | 11 |
| 12. | |  | 1. FC Lok Leipzig | 6 | 3-1-2 | 12:6 | 6 | 10 |
| 13. | |  | SV Tasmania Berlin | 9 | 2-3-4 | 10:23 | -13 | 9 |
| 14. | |  | SV Lichtenberg 47 | 10 | 2-2-6 | 6:14 | -8 | 8 |
| 15. | |  | FSV Union Fürstenwalde | 10 | 2-2-6 | 14:27 | -13 | 8 |
| 16. | |  | Tennis Borussia Berlin | 5 | 2-1-2 | 7:7 | 0 | 7 |
| 17. | |  | FSV Optik Rathenow | 10 | 1-4-5 | 9:19 | -10 | 7 |
| 18. | |  | ZFC Meuselwitz | 9 | 2-0-7 | 9:16 | -7 | 6 |
| 19. | |  | FC Eilenburg | 10 | 0-3-7 | 5:20 | -15 | 3 |
| 20. | |  | VfB Auerbach | 8 | 1-0-7 | 8:27 | -19 | 3 |