| Fr., 17.09.2021 | SV Babelsberg 03 - Tennis Borussia Berlin | 4:2 |
| Sa., 18.09.2021 | FSV 63 Luckenwalde - BFC Dynamo | 1:1 |
| Sa., 18.09.2021 | BSG Chemie Leipzig - FSV Optik Rathenow | 1:1 |
| So., 19.09.2021 | FC Eilenburg - 1. FC Lok Leipzig | 1:1 |
| So., 19.09.2021 | SV Tasmania Berlin - FSV Union Fürstenwalde | 3:3 |
| So., 19.09.2021 | ZFC Meuselwitz - Berliner AK 07 | 1:3 |
| Mi., 06.10.2021 | Hertha BSC Berlin II - FC Carl Zeiss Jena | 2:2 |
| Mi., 20.10.2021 | Chemnitzer FC - FC Energie Cottbus | 1:1 |
| Mi., 20.10.2021 | VfB Germania Halberstadt - VSG Altglienicke | 0:3 |
| Mi., 27.10.2021 | SV Lichtenberg 47 - VfB Auerbach | 1:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 11 | 9-1-1 | 28:10 | 18 | 28 |
| 2. | |  | Berliner AK 07 | 11 | 8-1-2 | 20:11 | 9 | 25 |
| 3. |  |  | FSV 63 Luckenwalde | 10 | 6-3-1 | 22:7 | 15 | 21 |
| 4. |  |  | VSG Altglienicke | 10 | 6-3-1 | 23:10 | 13 | 21 |
| 5. | |  | FC Carl Zeiss Jena | 9 | 6-1-2 | 19:6 | 13 | 19 |
| 6. | |  | SV Babelsberg 03 | 9 | 5-1-3 | 12:10 | 2 | 16 |
| 7. | |  | VfB Germania Halberstadt | 9 | 5-0-4 | 20:15 | 5 | 15 |
| 8. | |  | BSG Chemie Leipzig | 11 | 4-3-4 | 11:11 | 0 | 15 |
| 9. | |  | 1. FC Lok Leipzig | 8 | 4-2-2 | 17:7 | 10 | 14 |
| 10. | |  | FC Energie Cottbus | 7 | 4-1-2 | 17:7 | 10 | 13 |
| 11. | |  | Hertha BSC Berlin II | 9 | 3-3-3 | 10:13 | -3 | 12 |
| 12. | |  | Chemnitzer FC | 8 | 3-2-3 | 9:8 | 1 | 11 |
| 13. | |  | SV Tasmania Berlin | 10 | 2-4-4 | 13:26 | -13 | 10 |
| 14. | |  | FSV Union Fürstenwalde | 11 | 2-3-6 | 17:30 | -13 | 9 |
| 15. | |  | SV Lichtenberg 47 | 10 | 2-2-6 | 6:14 | -8 | 8 |
| 16. | |  | FSV Optik Rathenow | 11 | 1-5-5 | 10:20 | -10 | 8 |
| 17. | |  | Tennis Borussia Berlin | 7 | 2-1-4 | 9:15 | -6 | 7 |
| 18. | |  | ZFC Meuselwitz | 10 | 2-0-8 | 10:19 | -9 | 6 |
| 19. | |  | FC Eilenburg | 11 | 0-4-7 | 6:21 | -15 | 4 |
| 20. | |  | VfB Auerbach | 8 | 1-0-7 | 8:27 | -19 | 3 |