| Fr., 24.09.2021 | BFC Dynamo - Chemnitzer FC | 1:1 |
| Fr., 24.09.2021 | VSG Altglienicke - ZFC Meuselwitz | 1:0 |
| Fr., 24.09.2021 | Berliner AK 07 - SV Tasmania Berlin | 3:0 |
| Sa., 25.09.2021 | FC Carl Zeiss Jena - BSG Chemie Leipzig | 3:2 |
| Sa., 25.09.2021 | FSV Optik Rathenow - FSV 63 Luckenwalde | 0:1 |
| Sa., 25.09.2021 | FC Energie Cottbus - FC Eilenburg | 9:0 |
| Sa., 25.09.2021 | Tennis Borussia Berlin - SV Lichtenberg 47 | 3:2 |
| So., 26.09.2021 | VfB Auerbach - Hertha BSC Berlin II | 3:2 |
| So., 26.09.2021 | 1. FC Lok Leipzig - VfB Germania Halberstadt | 4:0 |
| So., 26.09.2021 | FSV Union Fürstenwalde - SV Babelsberg 03 | 1:4 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 12 | 9-2-1 | 29:11 | 18 | 29 |
| 2. | |  | Berliner AK 07 | 12 | 9-1-2 | 23:11 | 12 | 28 |
| 3. | |  | FSV 63 Luckenwalde | 12 | 7-4-1 | 24:8 | 16 | 25 |
| 4. | |  | VSG Altglienicke | 11 | 7-3-1 | 24:10 | 14 | 24 |
| 5. | |  | FC Carl Zeiss Jena | 10 | 7-1-2 | 22:8 | 14 | 22 |
| 6. | |  | SV Babelsberg 03 | 11 | 7-1-3 | 19:11 | 8 | 22 |
| 7. |  |  | 1. FC Lok Leipzig | 9 | 5-2-2 | 21:7 | 14 | 17 |
| 8. | |  | FC Energie Cottbus | 8 | 5-1-2 | 26:7 | 19 | 16 |
| 9. |  |  | VfB Germania Halberstadt | 10 | 5-0-5 | 20:19 | 1 | 15 |
| 10. | |  | BSG Chemie Leipzig | 12 | 4-3-5 | 13:14 | -1 | 15 |
| 11. | |  | Chemnitzer FC | 10 | 3-4-3 | 11:10 | 1 | 13 |
| 12. | |  | Hertha BSC Berlin II | 11 | 3-3-5 | 12:19 | -7 | 12 |
| 13. | |  | Tennis Borussia Berlin | 8 | 3-1-4 | 12:17 | -5 | 10 |
| 14. | |  | SV Tasmania Berlin | 11 | 2-4-5 | 13:29 | -16 | 10 |
| 15. | |  | FSV Union Fürstenwalde | 12 | 2-3-7 | 18:34 | -16 | 9 |
| 16. | |  | SV Lichtenberg 47 | 11 | 2-2-7 | 8:17 | -9 | 8 |
| 17. | |  | FSV Optik Rathenow | 12 | 1-5-6 | 10:21 | -11 | 8 |
| 18. | |  | ZFC Meuselwitz | 11 | 2-0-9 | 10:20 | -10 | 6 |
| 19. | |  | VfB Auerbach | 9 | 2-0-7 | 11:29 | -18 | 6 |
| 20. | |  | FC Eilenburg | 12 | 0-4-8 | 6:30 | -24 | 4 |