| Fr., 15.10.2021 | FC Carl Zeiss Jena - BFC Dynamo | 2:0 |
| Fr., 15.10.2021 | FSV Union Fürstenwalde - Hertha BSC Berlin II | 3:2 |
| Sa., 16.10.2021 | FSV Optik Rathenow - Chemnitzer FC | 1:2 |
| Sa., 16.10.2021 | VfB Auerbach - FSV 63 Luckenwalde | 1:0 |
| Sa., 16.10.2021 | FC Energie Cottbus - ZFC Meuselwitz | 3:0 |
| Sa., 16.10.2021 | 1. FC Lok Leipzig - SV Tasmania Berlin | 5:0 |
| Sa., 16.10.2021 | VSG Altglienicke - SV Babelsberg 03 | 1:1 |
| So., 17.10.2021 | FC Eilenburg - VfB Germania Halberstadt | 3:1 |
| So., 17.10.2021 | Berliner AK 07 - SV Lichtenberg 47 | 2:1 |
| So., 17.10.2021 | Tennis Borussia Berlin - BSG Chemie Leipzig | 0:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 14 | 11-1-2 | 27:13 | 14 | 34 |
| 2. | |  | BFC Dynamo | 14 | 9-3-2 | 30:14 | 16 | 30 |
| 3. | |  | 1. FC Lok Leipzig | 13 | 9-2-2 | 34:9 | 25 | 29 |
| 4. |  |  | VSG Altglienicke | 14 | 8-5-1 | 29:12 | 17 | 29 |
| 5. | |  | FC Carl Zeiss Jena | 13 | 8-3-2 | 26:10 | 16 | 27 |
| 6. |  |  | FSV 63 Luckenwalde | 14 | 7-5-2 | 24:9 | 15 | 26 |
| 7. | |  | SV Babelsberg 03 | 14 | 8-2-4 | 24:16 | 8 | 26 |
| 8. | |  | FC Energie Cottbus | 12 | 6-4-2 | 32:10 | 22 | 22 |
| 9. | |  | Chemnitzer FC | 14 | 5-5-4 | 18:15 | 3 | 20 |
| 10. | |  | BSG Chemie Leipzig | 14 | 5-4-5 | 15:15 | 0 | 19 |
| 11. | |  | VfB Germania Halberstadt | 13 | 5-1-7 | 21:25 | -4 | 16 |
| 12. | |  | Tennis Borussia Berlin | 12 | 4-2-6 | 16:23 | -7 | 14 |
| 13. | |  | Hertha BSC Berlin II | 14 | 3-4-7 | 16:25 | -9 | 13 |
| 14. | |  | FSV Union Fürstenwalde | 14 | 3-3-8 | 23:39 | -16 | 12 |
| 15. | |  | SV Lichtenberg 47 | 13 | 3-2-8 | 12:21 | -9 | 11 |
| 16. | |  | SV Tasmania Berlin | 13 | 2-5-6 | 14:35 | -21 | 11 |
| 17. | |  | VfB Auerbach | 13 | 3-1-9 | 15:34 | -19 | 10 |
| 18. | |  | FSV Optik Rathenow | 14 | 1-6-7 | 12:24 | -12 | 9 |
| 19. | |  | ZFC Meuselwitz | 14 | 3-0-11 | 13:28 | -15 | 9 |
| 20. | |  | FC Eilenburg | 14 | 1-4-9 | 9:33 | -24 | 7 |