| Fr., 22.10.2021 | FSV 63 Luckenwalde - Tennis Borussia Berlin | 0:1 |
| Fr., 22.10.2021 | SV Babelsberg 03 - 1. FC Lok Leipzig | 1:1 |
| Sa., 23.10.2021 | Chemnitzer FC - VfB Germania Halberstadt | 5:2 |
| Sa., 23.10.2021 | FSV Optik Rathenow - FC Carl Zeiss Jena | 1:3 |
| Sa., 23.10.2021 | SV Lichtenberg 47 - VSG Altglienicke | 3:0 |
| So., 24.10.2021 | BFC Dynamo - VfB Auerbach | 5:0 |
| So., 24.10.2021 | BSG Chemie Leipzig - FSV Union Fürstenwalde | 2:1 |
| So., 24.10.2021 | SV Tasmania Berlin - FC Energie Cottbus | 2:1 |
| So., 24.10.2021 | ZFC Meuselwitz - FC Eilenburg | 1:1 |
| Di., 02.11.2021 | Hertha BSC Berlin II - Berliner AK 07 | 1:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 14 | 11-1-2 | 27:13 | 14 | 34 |
| 2. | |  | BFC Dynamo | 15 | 10-3-2 | 35:14 | 21 | 33 |
| 3. | |  | 1. FC Lok Leipzig | 14 | 9-3-2 | 35:10 | 25 | 30 |
| 4. |  |  | FC Carl Zeiss Jena | 15 | 9-3-3 | 29:12 | 17 | 30 |
| 5. |  |  | VSG Altglienicke | 15 | 8-5-2 | 29:15 | 14 | 29 |
| 6. | |  | SV Babelsberg 03 | 15 | 8-3-4 | 25:17 | 8 | 27 |
| 7. | |  | FSV 63 Luckenwalde | 15 | 7-5-3 | 24:10 | 14 | 26 |
| 8. | |  | FC Energie Cottbus | 14 | 7-4-3 | 34:12 | 22 | 25 |
| 9. | |  | Chemnitzer FC | 15 | 6-5-4 | 23:17 | 6 | 23 |
| 10. | |  | BSG Chemie Leipzig | 15 | 6-4-5 | 17:16 | 1 | 22 |
| 11. | |  | Tennis Borussia Berlin | 14 | 6-2-6 | 19:23 | -4 | 20 |
| 12. | |  | VfB Germania Halberstadt | 15 | 5-1-9 | 23:32 | -9 | 16 |
| 13. | |  | SV Lichtenberg 47 | 15 | 4-3-8 | 16:22 | -6 | 15 |
| 14. | |  | SV Tasmania Berlin | 14 | 3-5-6 | 16:36 | -20 | 14 |
| 15. | |  | Hertha BSC Berlin II | 14 | 3-4-7 | 16:25 | -9 | 13 |
| 16. | |  | FSV Union Fürstenwalde | 15 | 3-3-9 | 24:41 | -17 | 12 |
| 17. | |  | VfB Auerbach | 15 | 3-2-10 | 16:40 | -24 | 11 |
| 18. | |  | ZFC Meuselwitz | 15 | 3-1-11 | 14:29 | -15 | 10 |
| 19. | |  | FSV Optik Rathenow | 15 | 1-6-8 | 13:27 | -14 | 9 |
| 20. | |  | FC Eilenburg | 15 | 1-5-9 | 10:34 | -24 | 8 |