| Fr., 29.10.2021 | VSG Altglienicke - Hertha BSC Berlin II | 1:3 |
| Fr., 29.10.2021 | Berliner AK 07 - BSG Chemie Leipzig | 3:0 |
| Sa., 30.10.2021 | FC Eilenburg - SV Tasmania Berlin | 3:0 |
| Sa., 30.10.2021 | 1. FC Lok Leipzig - SV Lichtenberg 47 | 1:3 |
| So., 31.10.2021 | Tennis Borussia Berlin - BFC Dynamo | 0:1 |
| So., 31.10.2021 | VfB Germania Halberstadt - ZFC Meuselwitz | 0:3 |
| So., 31.10.2021 | FC Energie Cottbus - SV Babelsberg 03 | 2:0 |
| So., 31.10.2021 | FSV Union Fürstenwalde - FSV 63 Luckenwalde | 0:3 |
| So., 31.10.2021 | FC Carl Zeiss Jena - Chemnitzer FC | 1:1 |
| Sa., 13.11.2021 | VfB Auerbach - FSV Optik Rathenow | 3:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 16 | 12-2-2 | 31:14 | 17 | 38 |
| 2. | |  | BFC Dynamo | 16 | 11-3-2 | 36:14 | 22 | 36 |
| 3. |  |  | FC Carl Zeiss Jena | 16 | 9-4-3 | 30:13 | 17 | 31 |
| 4. |  |  | 1. FC Lok Leipzig | 15 | 9-3-3 | 36:13 | 23 | 30 |
| 5. | |  | FSV 63 Luckenwalde | 16 | 8-5-3 | 27:10 | 17 | 29 |
| 6. | |  | VSG Altglienicke | 16 | 8-5-3 | 30:18 | 12 | 29 |
| 7. | |  | FC Energie Cottbus | 15 | 8-4-3 | 36:12 | 24 | 28 |
| 8. | |  | SV Babelsberg 03 | 16 | 8-3-5 | 25:19 | 6 | 27 |
| 9. | |  | Chemnitzer FC | 16 | 6-6-4 | 24:18 | 6 | 24 |
| 10. | |  | BSG Chemie Leipzig | 16 | 6-4-6 | 17:19 | -2 | 22 |
| 11. | |  | Tennis Borussia Berlin | 16 | 6-3-7 | 19:24 | -5 | 21 |
| 12. | |  | SV Lichtenberg 47 | 16 | 5-3-8 | 19:23 | -4 | 18 |
| 13. | |  | Hertha BSC Berlin II | 16 | 4-5-7 | 20:27 | -7 | 17 |
| 14. | |  | VfB Germania Halberstadt | 16 | 5-1-10 | 23:35 | -12 | 16 |
| 15. | |  | SV Tasmania Berlin | 16 | 3-6-7 | 16:39 | -23 | 15 |
| 16. | |  | ZFC Meuselwitz | 16 | 4-1-11 | 17:29 | -12 | 13 |
| 17. | |  | FSV Union Fürstenwalde | 16 | 3-3-10 | 24:44 | -20 | 12 |
| 18. | |  | FC Eilenburg | 16 | 2-5-9 | 13:34 | -21 | 11 |
| 19. | |  | VfB Auerbach | 15 | 3-2-10 | 16:40 | -24 | 11 |
| 20. | |  | FSV Optik Rathenow | 15 | 1-6-8 | 13:27 | -14 | 9 |