| Fr., 19.11.2021 | VfB Germania Halberstadt - SV Babelsberg 03 | 1:1 |
| Fr., 19.11.2021 | VSG Altglienicke - FSV 63 Luckenwalde | 2:1 |
| Sa., 20.11.2021 | Chemnitzer FC - VfB Auerbach | 5:1 |
| Sa., 20.11.2021 | FC Eilenburg - SV Lichtenberg 47 | 4:4 |
| Sa., 20.11.2021 | FC Energie Cottbus - Hertha BSC Berlin II | 2:2 |
| Sa., 20.11.2021 | ZFC Meuselwitz - SV Tasmania Berlin | 1:0 |
| So., 21.11.2021 | FSV Union Fürstenwalde - FSV Optik Rathenow | 0:0 |
| So., 21.11.2021 | Tennis Borussia Berlin - FC Carl Zeiss Jena | 4:1 |
| So., 21.11.2021 | 1. FC Lok Leipzig - BSG Chemie Leipzig | 1:0 |
| Di., 30.11.2021 | Berliner AK 07 - BFC Dynamo | 1:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | Berliner AK 07 | 17 | 13-2-2 | 32:14 | 18 | 41 |
| 2. | |  | BFC Dynamo | 17 | 12-3-2 | 41:16 | 25 | 39 |
| 3. | |  | 1. FC Lok Leipzig | 18 | 11-3-4 | 39:16 | 23 | 36 |
| 4. |  |  | FC Energie Cottbus | 18 | 10-5-3 | 45:15 | 30 | 35 |
| 5. |  |  | VSG Altglienicke | 18 | 10-5-3 | 33:19 | 14 | 35 |
| 6. | |  | FC Carl Zeiss Jena | 18 | 10-4-4 | 33:18 | 15 | 34 |
| 7. | |  | SV Babelsberg 03 | 18 | 9-4-5 | 27:20 | 7 | 31 |
| 8. | |  | FSV 63 Luckenwalde | 18 | 8-5-5 | 28:13 | 15 | 29 |
| 9. | |  | Chemnitzer FC | 18 | 7-7-4 | 30:20 | 10 | 28 |
| 10. | |  | Tennis Borussia Berlin | 18 | 8-3-7 | 26:26 | 0 | 27 |
| 11. | |  | BSG Chemie Leipzig | 18 | 6-4-8 | 17:21 | -4 | 22 |
| 12. | |  | SV Lichtenberg 47 | 18 | 5-4-9 | 23:31 | -8 | 19 |
| 13. | |  | Hertha BSC Berlin II | 18 | 4-6-8 | 22:30 | -8 | 18 |
| 14. | |  | VfB Germania Halberstadt | 18 | 5-3-10 | 24:36 | -12 | 18 |
| 15. | |  | ZFC Meuselwitz | 18 | 5-2-11 | 19:30 | -11 | 17 |
| 16. | |  | SV Tasmania Berlin | 18 | 3-7-8 | 16:40 | -24 | 16 |
| 17. | |  | FSV Union Fürstenwalde | 18 | 3-4-11 | 26:49 | -23 | 13 |
| 18. | |  | FC Eilenburg | 18 | 2-6-10 | 17:39 | -22 | 12 |
| 19. | |  | VfB Auerbach | 18 | 3-3-12 | 21:50 | -29 | 12 |
| 20. | |  | FSV Optik Rathenow | 18 | 1-8-9 | 17:33 | -16 | 11 |