| Fr., 26.11.2021 | FSV Optik Rathenow - Berliner AK 07 | 3:1 |
| Fr., 26.11.2021 | BFC Dynamo - VSG Altglienicke | 2:0 |
| Sa., 27.11.2021 | SV Babelsberg 03 - ZFC Meuselwitz | 0:2 |
| Sa., 27.11.2021 | BSG Chemie Leipzig - FC Energie Cottbus | 1:2 |
| So., 28.11.2021 | SV Tasmania Berlin - Chemnitzer FC | 0:2 |
| So., 28.11.2021 | VfB Auerbach - Tennis Borussia Berlin | 0:4 |
| So., 28.11.2021 | FC Carl Zeiss Jena - FSV Union Fürstenwalde | 4:1 |
| So., 28.11.2021 | Hertha BSC Berlin II - FC Eilenburg | 5:1 |
| So., 28.11.2021 | SV Lichtenberg 47 - VfB Germania Halberstadt | 0:0 |
| Mi., 02.02.2022 | FSV 63 Luckenwalde - 1. FC Lok Leipzig | 2:3 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 19 | 14-3-2 | 46:17 | 29 | 45 |
| 2. |  |  | Berliner AK 07 | 19 | 13-2-4 | 34:20 | 14 | 41 |
| 3. | |  | FC Energie Cottbus | 19 | 11-5-3 | 47:16 | 31 | 38 |
| 4. | |  | FC Carl Zeiss Jena | 19 | 11-4-4 | 37:19 | 18 | 37 |
| 5. | |  | 1. FC Lok Leipzig | 18 | 11-3-4 | 39:16 | 23 | 36 |
| 6. | |  | VSG Altglienicke | 19 | 10-5-4 | 33:21 | 12 | 35 |
| 7. | |  | Chemnitzer FC | 19 | 8-7-4 | 32:20 | 12 | 31 |
| 8. | |  | SV Babelsberg 03 | 19 | 9-4-6 | 27:22 | 5 | 31 |
| 9. | |  | Tennis Borussia Berlin | 19 | 9-3-7 | 30:26 | 4 | 30 |
| 10. | |  | FSV 63 Luckenwalde | 18 | 8-5-5 | 28:13 | 15 | 29 |
| 11. |  |  | BSG Chemie Leipzig | 19 | 6-4-9 | 18:23 | -5 | 22 |
| 12. | |  | Hertha BSC Berlin II | 19 | 5-6-8 | 27:31 | -4 | 21 |
| 13. | |  | SV Lichtenberg 47 | 19 | 5-5-9 | 23:31 | -8 | 20 |
| 14. | |  | ZFC Meuselwitz | 19 | 6-2-11 | 21:30 | -9 | 20 |
| 15. | |  | VfB Germania Halberstadt | 19 | 5-4-10 | 24:36 | -12 | 19 |
| 16. | |  | SV Tasmania Berlin | 19 | 3-7-9 | 16:42 | -26 | 16 |
| 17. | |  | FSV Optik Rathenow | 19 | 2-8-9 | 20:34 | -14 | 14 |
| 18. | |  | FSV Union Fürstenwalde | 19 | 3-4-12 | 27:53 | -26 | 13 |
| 19. | |  | FC Eilenburg | 19 | 2-6-11 | 18:44 | -26 | 12 |
| 20. | |  | VfB Auerbach | 19 | 3-3-13 | 21:54 | -33 | 12 |