| Fr., 17.12.2021 | Tennis Borussia Berlin - Berliner AK 07 | 1:2 |
| Fr., 17.12.2021 | Hertha BSC Berlin II - SV Tasmania Berlin | 5:3 |
| Sa., 18.12.2021 | FSV 63 Luckenwalde - VfB Germania Halberstadt | 2:2 |
| Sa., 18.12.2021 | FSV Optik Rathenow - FC Energie Cottbus | 0:2 |
| So., 19.12.2021 | FSV Union Fürstenwalde - Chemnitzer FC | 1:3 |
| So., 19.12.2021 | BFC Dynamo - FC Eilenburg | 6:0 |
| So., 19.12.2021 | SV Lichtenberg 47 - SV Babelsberg 03 | 0:1 |
| Sa., 22.01.2022 | FC Carl Zeiss Jena - 1. FC Lok Leipzig | 2:3 |
| Mi., 09.02.2022 | BSG Chemie Leipzig - ZFC Meuselwitz | 0:0 |
| Mi., 09.03.2022 | VfB Auerbach - VSG Altglienicke | 2:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 22 | 15-4-3 | 54:20 | 34 | 49 |
| 2. | |  | FC Energie Cottbus | 22 | 13-6-3 | 53:19 | 34 | 45 |
| 3. | |  | Berliner AK 07 | 21 | 14-2-5 | 36:23 | 13 | 44 |
| 4. |  |  | 1. FC Lok Leipzig | 20 | 13-3-4 | 44:19 | 25 | 42 |
| 5. |  |  | FC Carl Zeiss Jena | 21 | 12-4-5 | 41:22 | 19 | 40 |
| 6. | |  | Chemnitzer FC | 22 | 10-8-4 | 37:22 | 15 | 38 |
| 7. | |  | VSG Altglienicke | 20 | 11-5-4 | 37:23 | 14 | 38 |
| 8. | |  | SV Babelsberg 03 | 22 | 11-5-6 | 30:22 | 8 | 38 |
| 9. | |  | FSV 63 Luckenwalde | 21 | 8-6-7 | 33:20 | 13 | 30 |
| 10. | |  | Hertha BSC Berlin II | 22 | 8-6-8 | 37:34 | 3 | 30 |
| 11. | |  | Tennis Borussia Berlin | 21 | 9-3-9 | 32:30 | 2 | 30 |
| 12. | |  | BSG Chemie Leipzig | 21 | 8-4-9 | 22:24 | -2 | 28 |
| 13. | |  | SV Lichtenberg 47 | 21 | 5-6-10 | 24:33 | -9 | 21 |
| 14. | |  | ZFC Meuselwitz | 21 | 6-3-12 | 22:33 | -11 | 21 |
| 15. | |  | VfB Germania Halberstadt | 22 | 5-5-12 | 26:43 | -17 | 20 |
| 16. | |  | SV Tasmania Berlin | 21 | 3-7-11 | 19:49 | -30 | 16 |
| 17. | |  | FC Eilenburg | 22 | 3-6-13 | 21:53 | -32 | 15 |
| 18. | |  | FSV Optik Rathenow | 21 | 2-8-11 | 22:40 | -18 | 14 |
| 19. | |  | FSV Union Fürstenwalde | 20 | 3-4-13 | 28:56 | -28 | 13 |
| 20. | |  | VfB Auerbach | 19 | 3-3-13 | 21:54 | -33 | 12 |