| Fr., 28.01.2022 | VfB Germania Halberstadt - BFC Dynamo | 0:2 |
| Fr., 28.01.2022 | ZFC Meuselwitz - FSV 63 Luckenwalde | 0:2 |
| Sa., 29.01.2022 | Chemnitzer FC - SV Lichtenberg 47 | 0:0 |
| Sa., 29.01.2022 | 1. FC Lok Leipzig - VfB Auerbach | 1:0 |
| Sa., 29.01.2022 | FC Energie Cottbus - FC Carl Zeiss Jena | 0:1 |
| Sa., 29.01.2022 | FC Eilenburg - FSV Optik Rathenow | 4:0 |
| So., 30.01.2022 | VSG Altglienicke - Tennis Borussia Berlin | 0:3 |
| So., 30.01.2022 | SV Tasmania Berlin - BSG Chemie Leipzig | 0:1 |
| So., 30.01.2022 | SV Babelsberg 03 - Hertha BSC Berlin II | 3:0 |
| So., 30.01.2022 | Berliner AK 07 - FSV Union Fürstenwalde | 2:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 23 | 16-4-3 | 56:20 | 36 | 52 |
| 2. |  |  | 1. FC Lok Leipzig | 22 | 15-3-4 | 48:21 | 27 | 48 |
| 3. | |  | Berliner AK 07 | 23 | 15-3-5 | 38:24 | 14 | 48 |
| 4. |  |  | FC Energie Cottbus | 23 | 13-6-4 | 53:20 | 33 | 45 |
| 5. | |  | FC Carl Zeiss Jena | 22 | 13-4-5 | 42:22 | 20 | 43 |
| 6. | |  | SV Babelsberg 03 | 23 | 12-5-6 | 33:22 | 11 | 41 |
| 7. | |  | Chemnitzer FC | 23 | 10-9-4 | 37:22 | 15 | 39 |
| 8. | |  | VSG Altglienicke | 21 | 11-5-5 | 37:26 | 11 | 38 |
| 9. | |  | Tennis Borussia Berlin | 23 | 10-4-9 | 36:31 | 5 | 34 |
| 10. | |  | FSV 63 Luckenwalde | 23 | 9-6-8 | 37:23 | 14 | 33 |
| 11. | |  | BSG Chemie Leipzig | 22 | 9-4-9 | 23:24 | -1 | 31 |
| 12. | |  | Hertha BSC Berlin II | 23 | 8-6-9 | 37:37 | 0 | 30 |
| 13. | |  | SV Lichtenberg 47 | 23 | 6-7-10 | 28:33 | -5 | 25 |
| 14. | |  | ZFC Meuselwitz | 22 | 6-3-13 | 22:35 | -13 | 21 |
| 15. | |  | VfB Germania Halberstadt | 23 | 5-5-13 | 26:45 | -19 | 20 |
| 16. | |  | FC Eilenburg | 23 | 4-6-13 | 25:53 | -28 | 18 |
| 17. | |  | SV Tasmania Berlin | 23 | 3-7-13 | 19:54 | -35 | 16 |
| 18. | |  | FSV Optik Rathenow | 22 | 2-8-12 | 22:44 | -22 | 14 |
| 19. | |  | FSV Union Fürstenwalde | 22 | 3-5-14 | 30:59 | -29 | 14 |
| 20. | |  | VfB Auerbach | 21 | 3-4-14 | 21:55 | -34 | 13 |