| Di., 05.04.2022 | FSV Optik Rathenow - BFC Dynamo | 0:4 |
| Di., 05.04.2022 | FSV Union Fürstenwalde - SV Lichtenberg 47 | 2:0 |
| Di., 05.04.2022 | Berliner AK 07 - SV Babelsberg 03 | 2:2 |
| Di., 05.04.2022 | VSG Altglienicke - SV Tasmania Berlin | 5:1 |
| Mi., 06.04.2022 | FC Eilenburg - Chemnitzer FC | 1:2 |
| Mi., 06.04.2022 | 1. FC Lok Leipzig - ZFC Meuselwitz | 2:0 |
| Mi., 06.04.2022 | FC Energie Cottbus - VfB Germania Halberstadt | 3:1 |
| Mi., 06.04.2022 | FC Carl Zeiss Jena - FSV 63 Luckenwalde | 2:0 |
| Mi., 06.04.2022 | VfB Auerbach - BSG Chemie Leipzig | 1:3 |
| Mi., 06.04.2022 | Tennis Borussia Berlin - Hertha BSC Berlin II | 0:4 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 32 | 23-5-4 | 74:23 | 51 | 74 |
| 2. | |  | VSG Altglienicke | 32 | 19-7-6 | 66:35 | 31 | 64 |
| 3. | |  | 1. FC Lok Leipzig | 30 | 19-6-5 | 63:30 | 33 | 63 |
| 4. | |  | FC Carl Zeiss Jena | 32 | 19-6-7 | 56:28 | 28 | 63 |
| 5. |  |  | FC Energie Cottbus | 31 | 16-9-6 | 64:30 | 34 | 57 |
| 6. | |  | Chemnitzer FC | 31 | 16-9-6 | 51:32 | 19 | 57 |
| 7. |  |  | Berliner AK 07 | 32 | 17-5-10 | 47:37 | 10 | 56 |
| 8. | |  | Hertha BSC Berlin II | 32 | 14-6-12 | 55:43 | 12 | 48 |
| 9. | |  | Tennis Borussia Berlin | 32 | 13-9-10 | 52:43 | 9 | 48 |
| 10. | |  | SV Babelsberg 03 | 32 | 13-9-10 | 41:34 | 7 | 48 |
| 11. | |  | BSG Chemie Leipzig | 32 | 13-7-12 | 39:38 | 1 | 46 |
| 12. | |  | FSV 63 Luckenwalde | 32 | 12-7-13 | 51:42 | 9 | 43 |
| 13. | |  | SV Lichtenberg 47 | 31 | 9-8-14 | 37:47 | -10 | 35 |
| 14. | |  | ZFC Meuselwitz | 32 | 9-6-17 | 31:47 | -16 | 33 |
| 15. | |  | VfB Germania Halberstadt | 32 | 7-8-17 | 39:62 | -23 | 29 |
| 16. | |  | FC Eilenburg | 32 | 6-9-17 | 33:68 | -35 | 27 |
| 17. | |  | FSV Union Fürstenwalde | 32 | 6-7-19 | 45:80 | -35 | 25 |
| 18. | |  | FSV Optik Rathenow | 32 | 3-13-16 | 32:63 | -31 | 22 |
| 19. | |  | VfB Auerbach | 31 | 5-7-19 | 39:74 | -35 | 22 |
| 20. | |  | SV Tasmania Berlin | 32 | 3-7-22 | 26:85 | -59 | 16 |