| Fr., 08.04.2022 | SV Babelsberg 03 - VSG Altglienicke | 2:2 |
| Fr., 08.04.2022 | SV Lichtenberg 47 - Berliner AK 07 | 1:5 |
| Sa., 09.04.2022 | SV Tasmania Berlin - 1. FC Lok Leipzig | 1:1 |
| Sa., 09.04.2022 | Chemnitzer FC - FSV Optik Rathenow | 1:1 |
| Sa., 09.04.2022 | VfB Germania Halberstadt - FC Eilenburg | 2:1 |
| Sa., 09.04.2022 | BSG Chemie Leipzig - Tennis Borussia Berlin | 2:1 |
| So., 10.04.2022 | FSV 63 Luckenwalde - VfB Auerbach | 3:0 |
| So., 10.04.2022 | Hertha BSC Berlin II - FSV Union Fürstenwalde | 5:0 |
| So., 10.04.2022 | ZFC Meuselwitz - FC Energie Cottbus | 1:4 |
| So., 10.04.2022 | BFC Dynamo - FC Carl Zeiss Jena | 1:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 33 | 23-5-5 | 75:25 | 50 | 74 |
| 2. |  |  | FC Carl Zeiss Jena | 33 | 20-6-7 | 58:29 | 29 | 66 |
| 3. |  |  | VSG Altglienicke | 33 | 19-8-6 | 68:37 | 31 | 65 |
| 4. | |  | 1. FC Lok Leipzig | 32 | 19-7-6 | 65:33 | 32 | 64 |
| 5. | |  | Chemnitzer FC | 33 | 17-10-6 | 54:34 | 20 | 61 |
| 6. | |  | FC Energie Cottbus | 32 | 17-9-6 | 68:31 | 37 | 60 |
| 7. | |  | Berliner AK 07 | 33 | 18-5-10 | 52:38 | 14 | 59 |
| 8. | |  | Hertha BSC Berlin II | 33 | 15-6-12 | 60:43 | 17 | 51 |
| 9. | |  | SV Babelsberg 03 | 33 | 13-10-10 | 43:36 | 7 | 49 |
| 10. | |  | BSG Chemie Leipzig | 33 | 14-7-12 | 41:39 | 2 | 49 |
| 11. | |  | Tennis Borussia Berlin | 33 | 13-9-11 | 53:45 | 8 | 48 |
| 12. | |  | FSV 63 Luckenwalde | 33 | 13-7-13 | 54:42 | 12 | 46 |
| 13. | |  | SV Lichtenberg 47 | 33 | 10-8-15 | 39:52 | -13 | 38 |
| 14. | |  | ZFC Meuselwitz | 33 | 9-6-18 | 32:51 | -19 | 33 |
| 15. | |  | VfB Germania Halberstadt | 33 | 8-8-17 | 41:63 | -22 | 32 |
| 16. | |  | FC Eilenburg | 33 | 6-9-18 | 34:70 | -36 | 27 |
| 17. | |  | FSV Union Fürstenwalde | 33 | 6-7-20 | 45:85 | -40 | 25 |
| 18. | |  | FSV Optik Rathenow | 33 | 3-14-16 | 33:64 | -31 | 23 |
| 19. | |  | VfB Auerbach | 33 | 5-7-21 | 39:78 | -39 | 22 |
| 20. | |  | SV Tasmania Berlin | 33 | 3-8-22 | 27:86 | -59 | 17 |