| Do., 14.04.2022 | FC Eilenburg - ZFC Meuselwitz | 0:2 |
| Do., 14.04.2022 | Tennis Borussia Berlin - FSV 63 Luckenwalde | 0:0 |
| Do., 14.04.2022 | FC Energie Cottbus - SV Tasmania Berlin | 5:0 |
| Sa., 16.04.2022 | VfB Germania Halberstadt - Chemnitzer FC | 0:2 |
| Sa., 16.04.2022 | FC Carl Zeiss Jena - FSV Optik Rathenow | 6:2 |
| Sa., 16.04.2022 | Berliner AK 07 - Hertha BSC Berlin II | 2:2 |
| Sa., 16.04.2022 | 1. FC Lok Leipzig - SV Babelsberg 03 | 1:0 |
| So., 17.04.2022 | FSV Union Fürstenwalde - BSG Chemie Leipzig | 0:0 |
| So., 17.04.2022 | VSG Altglienicke - SV Lichtenberg 47 | 4:2 |
| So., 17.04.2022 | VfB Auerbach - BFC Dynamo | 2:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 34 | 23-6-5 | 77:27 | 50 | 75 |
| 2. | |  | FC Carl Zeiss Jena | 34 | 21-6-7 | 64:31 | 33 | 69 |
| 3. | |  | VSG Altglienicke | 34 | 20-8-6 | 72:39 | 33 | 68 |
| 4. | |  | 1. FC Lok Leipzig | 34 | 20-8-6 | 67:34 | 33 | 68 |
| 5. |  |  | FC Energie Cottbus | 34 | 18-10-6 | 74:32 | 42 | 64 |
| 6. |  |  | Chemnitzer FC | 34 | 18-10-6 | 56:34 | 22 | 64 |
| 7. | |  | Berliner AK 07 | 34 | 18-6-10 | 54:40 | 14 | 60 |
| 8. | |  | Hertha BSC Berlin II | 34 | 15-7-12 | 62:45 | 17 | 52 |
| 9. | |  | BSG Chemie Leipzig | 34 | 14-8-12 | 41:39 | 2 | 50 |
| 10. | |  | Tennis Borussia Berlin | 34 | 13-10-11 | 53:45 | 8 | 49 |
| 11. | |  | SV Babelsberg 03 | 34 | 13-10-11 | 43:37 | 6 | 49 |
| 12. | |  | FSV 63 Luckenwalde | 34 | 13-8-13 | 54:42 | 12 | 47 |
| 13. | |  | SV Lichtenberg 47 | 34 | 10-8-16 | 41:56 | -15 | 38 |
| 14. | |  | ZFC Meuselwitz | 34 | 10-6-18 | 34:51 | -17 | 36 |
| 15. | |  | VfB Germania Halberstadt | 34 | 8-8-18 | 41:65 | -24 | 32 |
| 16. | |  | FC Eilenburg | 34 | 6-9-19 | 34:72 | -38 | 27 |
| 17. | |  | FSV Union Fürstenwalde | 34 | 6-8-20 | 45:85 | -40 | 26 |
| 18. | |  | FSV Optik Rathenow | 34 | 3-14-17 | 35:70 | -35 | 23 |
| 19. | |  | VfB Auerbach | 34 | 5-8-21 | 41:80 | -39 | 23 |
| 20. | |  | SV Tasmania Berlin | 34 | 3-8-23 | 27:91 | -64 | 17 |