| Fr., 29.04.2022 | ZFC Meuselwitz - Chemnitzer FC | 1:1 |
| Fr., 29.04.2022 | VfB Auerbach - FC Carl Zeiss Jena | 1:4 |
| Fr., 29.04.2022 | Tennis Borussia Berlin - FSV Optik Rathenow | 2:2 |
| Fr., 29.04.2022 | FSV Union Fürstenwalde - BFC Dynamo | 1:1 |
| Fr., 29.04.2022 | VSG Altglienicke - BSG Chemie Leipzig | 2:3 |
| Fr., 29.04.2022 | FC Eilenburg - SV Babelsberg 03 | 1:0 |
| Sa., 30.04.2022 | Berliner AK 07 - FSV 63 Luckenwalde | 0:2 |
| Sa., 30.04.2022 | 1. FC Lok Leipzig - Hertha BSC Berlin II | 0:2 |
| So., 01.05.2022 | FC Energie Cottbus - SV Lichtenberg 47 | 4:1 |
| So., 01.05.2022 | VfB Germania Halberstadt - SV Tasmania Berlin | 3:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 36 | 24-7-5 | 79:28 | 51 | 79 |
| 2. | |  | FC Carl Zeiss Jena | 36 | 22-7-7 | 69:33 | 36 | 73 |
| 3. |  |  | FC Energie Cottbus | 36 | 20-10-6 | 80:33 | 47 | 70 |
| 4. |  |  | VSG Altglienicke | 36 | 20-9-7 | 75:43 | 32 | 69 |
| 5. | |  | 1. FC Lok Leipzig | 36 | 20-8-8 | 67:39 | 28 | 68 |
| 6. | |  | Chemnitzer FC | 36 | 18-12-6 | 58:36 | 22 | 66 |
| 7. | |  | Berliner AK 07 | 36 | 19-6-11 | 56:42 | 14 | 63 |
| 8. | |  | Hertha BSC Berlin II | 36 | 16-8-12 | 65:46 | 19 | 56 |
| 9. | |  | BSG Chemie Leipzig | 36 | 15-8-13 | 44:43 | 1 | 53 |
| 10. | |  | FSV 63 Luckenwalde | 36 | 14-8-14 | 57:44 | 13 | 50 |
| 11. | |  | Tennis Borussia Berlin | 36 | 13-11-12 | 55:48 | 7 | 50 |
| 12. | |  | SV Babelsberg 03 | 36 | 13-10-13 | 43:40 | 3 | 49 |
| 13. | |  | SV Lichtenberg 47 | 36 | 11-8-17 | 45:60 | -15 | 41 |
| 14. | |  | VfB Germania Halberstadt | 36 | 10-8-18 | 45:65 | -20 | 38 |
| 15. | |  | ZFC Meuselwitz | 36 | 10-7-19 | 35:53 | -18 | 37 |
| 16. | |  | FC Eilenburg | 36 | 8-9-19 | 37:73 | -36 | 33 |
| 17. | |  | FSV Union Fürstenwalde | 36 | 7-9-20 | 48:87 | -39 | 30 |
| 18. | |  | FSV Optik Rathenow | 36 | 4-15-17 | 41:74 | -33 | 27 |
| 19. | |  | VfB Auerbach | 36 | 5-8-23 | 44:88 | -44 | 23 |
| 20. | |  | SV Tasmania Berlin | 36 | 3-8-25 | 28:96 | -68 | 17 |