| Sa., 07.05.2022 | FC Carl Zeiss Jena - Tennis Borussia Berlin | 2:1 |
| Sa., 07.05.2022 | BSG Chemie Leipzig - 1. FC Lok Leipzig | 2:1 |
| Sa., 07.05.2022 | BFC Dynamo - Berliner AK 07 | 1:2 |
| So., 08.05.2022 | VfB Auerbach - Chemnitzer FC | 1:4 |
| So., 08.05.2022 | SV Tasmania Berlin - ZFC Meuselwitz | 0:6 |
| So., 08.05.2022 | SV Babelsberg 03 - VfB Germania Halberstadt | 2:1 |
| So., 08.05.2022 | SV Lichtenberg 47 - FC Eilenburg | 3:2 |
| So., 08.05.2022 | Hertha BSC Berlin II - FC Energie Cottbus | 1:1 |
| So., 08.05.2022 | FSV 63 Luckenwalde - VSG Altglienicke | 0:3 |
| So., 08.05.2022 | FSV Optik Rathenow - FSV Union Fürstenwalde | 2:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 37 | 24-7-6 | 80:30 | 50 | 79 |
| 2. | |  | FC Carl Zeiss Jena | 37 | 23-7-7 | 71:34 | 37 | 76 |
| 3. |  |  | VSG Altglienicke | 37 | 21-9-7 | 78:43 | 35 | 72 |
| 4. |  |  | FC Energie Cottbus | 37 | 20-11-6 | 81:34 | 47 | 71 |
| 5. | |  | Chemnitzer FC | 37 | 19-12-6 | 62:37 | 25 | 69 |
| 6. | |  | 1. FC Lok Leipzig | 37 | 20-8-9 | 68:41 | 27 | 68 |
| 7. | |  | Berliner AK 07 | 37 | 20-6-11 | 58:43 | 15 | 66 |
| 8. | |  | Hertha BSC Berlin II | 37 | 16-9-12 | 66:47 | 19 | 57 |
| 9. | |  | BSG Chemie Leipzig | 37 | 16-8-13 | 46:44 | 2 | 56 |
| 10. | |  | SV Babelsberg 03 | 37 | 14-10-13 | 45:41 | 4 | 52 |
| 11. | |  | FSV 63 Luckenwalde | 37 | 14-8-15 | 57:47 | 10 | 50 |
| 12. | |  | Tennis Borussia Berlin | 37 | 13-11-13 | 56:50 | 6 | 50 |
| 13. | |  | SV Lichtenberg 47 | 37 | 12-8-17 | 48:62 | -14 | 44 |
| 14. | |  | ZFC Meuselwitz | 37 | 11-7-19 | 41:53 | -12 | 40 |
| 15. | |  | VfB Germania Halberstadt | 37 | 10-8-19 | 46:67 | -21 | 38 |
| 16. | |  | FC Eilenburg | 37 | 8-9-20 | 39:76 | -37 | 33 |
| 17. | |  | FSV Optik Rathenow | 37 | 5-15-17 | 43:74 | -31 | 30 |
| 18. | |  | FSV Union Fürstenwalde | 37 | 7-9-21 | 48:89 | -41 | 30 |
| 19. | |  | VfB Auerbach | 37 | 5-8-24 | 45:92 | -47 | 23 |
| 20. | |  | SV Tasmania Berlin | 37 | 3-8-26 | 28:102 | -74 | 17 |