| Fr., 13.08.2021 | VfB Germania Halberstadt - FSV Optik Rathenow | 2:0 |
| Fr., 13.08.2021 | FC Eilenburg - FC Carl Zeiss Jena | 1:3 |
| Fr., 13.08.2021 | SV Babelsberg 03 - BSG Chemie Leipzig | 0:2 |
| Fr., 13.08.2021 | SV Tasmania Berlin - FSV 63 Luckenwalde | 0:4 |
| Sa., 14.08.2021 | FC Energie Cottbus - VfB Auerbach | 5:0 |
| Sa., 14.08.2021 | VSG Altglienicke - FSV Union Fürstenwalde | 3:3 |
| Sa., 14.08.2021 | SV Lichtenberg 47 - Hertha BSC Berlin II | 0:0 |
| So., 15.08.2021 | Chemnitzer FC - Berliner AK 07 | 0:0 |
| So., 15.08.2021 | ZFC Meuselwitz - BFC Dynamo | 2:3 |
| Mi., 22.09.2021 | 1. FC Lok Leipzig - Tennis Borussia Berlin | 4:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | FSV 63 Luckenwalde | 5 | 4-1-0 | 14:2 | 12 | 13 |
| 2. |  |  | Berliner AK 07 | 5 | 4-1-0 | 10:2 | 8 | 13 |
| 3. |  |  | BFC Dynamo | 4 | 4-0-0 | 11:4 | 7 | 12 |
| 4. | |  | Chemnitzer FC | 5 | 3-1-1 | 8:4 | 4 | 10 |
| 5. | |  | BSG Chemie Leipzig | 5 | 3-1-1 | 7:4 | 3 | 10 |
| 6. | |  | VfB Germania Halberstadt | 4 | 3-0-1 | 8:5 | 3 | 9 |
| 7. | |  | VSG Altglienicke | 4 | 2-2-0 | 9:6 | 3 | 8 |
| 8. | |  | FC Energie Cottbus | 4 | 2-1-1 | 8:3 | 5 | 7 |
| 9. | |  | SV Babelsberg 03 | 4 | 2-0-2 | 3:5 | -2 | 6 |
| 10. | |  | Hertha BSC Berlin II | 4 | 1-2-1 | 2:5 | -3 | 5 |
| 11. | |  | SV Tasmania Berlin | 5 | 1-2-2 | 4:8 | -4 | 5 |
| 12. | |  | FC Carl Zeiss Jena | 4 | 1-1-2 | 4:4 | 0 | 4 |
| 13. | |  | 1. FC Lok Leipzig | 3 | 1-1-1 | 4:4 | 0 | 4 |
| 14. | |  | FSV Union Fürstenwalde | 5 | 1-1-3 | 9:13 | -4 | 4 |
| 15. | |  | Tennis Borussia Berlin | 3 | 1-0-2 | 4:6 | -2 | 3 |
| 16. | |  | ZFC Meuselwitz | 5 | 1-0-4 | 5:9 | -4 | 3 |
| 17. | |  | SV Lichtenberg 47 | 5 | 0-2-3 | 2:6 | -4 | 2 |
| 18. | |  | FC Eilenburg | 5 | 0-2-3 | 3:8 | -5 | 2 |
| 19. | |  | FSV Optik Rathenow | 5 | 0-2-3 | 2:8 | -6 | 2 |
| 20. | |  | VfB Auerbach | 4 | 0-0-4 | 4:15 | -11 | 0 |