| Fr., 20.08.2021 | SV Lichtenberg 47 - FSV 63 Luckenwalde | 0:3 |
| Sa., 21.08.2021 | Chemnitzer FC - VSG Altglienicke | 0:2 |
| Sa., 21.08.2021 | FC Energie Cottbus - FSV Union Fürstenwalde | 6:1 |
| Sa., 21.08.2021 | 1. FC Lok Leipzig - Berliner AK 07 | 1:2 |
| Sa., 21.08.2021 | SV Tasmania Berlin - FSV Optik Rathenow | 3:3 |
| Sa., 21.08.2021 | ZFC Meuselwitz - FC Carl Zeiss Jena | 1:3 |
| So., 22.08.2021 | VfB Germania Halberstadt - VfB Auerbach | 7:1 |
| So., 22.08.2021 | FC Eilenburg - Tennis Borussia Berlin | 0:2 |
| So., 22.08.2021 | Hertha BSC Berlin II - BSG Chemie Leipzig | 0:1 |
| So., 22.08.2021 | SV Babelsberg 03 - BFC Dynamo | 2:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | FSV 63 Luckenwalde | 7 | 5-2-0 | 17:2 | 15 | 17 |
| 2. | |  | Berliner AK 07 | 7 | 5-1-1 | 12:5 | 7 | 16 |
| 3. |  |  | BFC Dynamo | 6 | 5-0-1 | 18:6 | 12 | 15 |
| 4. |  |  | VSG Altglienicke | 6 | 4-2-0 | 13:6 | 7 | 14 |
| 5. | |  | BSG Chemie Leipzig | 7 | 4-1-2 | 8:5 | 3 | 13 |
| 6. | |  | VfB Germania Halberstadt | 6 | 4-0-2 | 16:8 | 8 | 12 |
| 7. | |  | FC Energie Cottbus | 5 | 3-1-1 | 14:4 | 10 | 10 |
| 8. | |  | FC Carl Zeiss Jena | 6 | 3-1-2 | 9:6 | 3 | 10 |
| 9. | |  | Chemnitzer FC | 7 | 3-1-3 | 8:7 | 1 | 10 |
| 10. | |  | SV Babelsberg 03 | 6 | 3-1-2 | 5:6 | -1 | 10 |
| 11. | |  | Hertha BSC Berlin II | 6 | 2-2-2 | 3:6 | -3 | 8 |
| 12. | |  | 1. FC Lok Leipzig | 5 | 2-1-2 | 9:6 | 3 | 7 |
| 13. | |  | Tennis Borussia Berlin | 4 | 2-0-2 | 6:6 | 0 | 6 |
| 14. | |  | FSV Optik Rathenow | 7 | 1-3-3 | 7:12 | -5 | 6 |
| 15. | |  | SV Tasmania Berlin | 7 | 1-3-3 | 7:17 | -10 | 6 |
| 16. | |  | SV Lichtenberg 47 | 7 | 1-2-4 | 3:9 | -6 | 5 |
| 17. | |  | FSV Union Fürstenwalde | 7 | 1-1-5 | 10:23 | -13 | 4 |
| 18. | |  | ZFC Meuselwitz | 7 | 1-0-6 | 7:14 | -7 | 3 |
| 19. | |  | VfB Auerbach | 6 | 1-0-5 | 7:23 | -16 | 3 |
| 20. | |  | FC Eilenburg | 7 | 0-2-5 | 4:12 | -8 | 2 |