| Di., 31.08.2021 | BSG Chemie Leipzig - FSV 63 Luckenwalde | 1:2 |
| Di., 31.08.2021 | Hertha BSC Berlin II - BFC Dynamo | 2:3 |
| Di., 31.08.2021 | SV Lichtenberg 47 - FSV Optik Rathenow | 2:0 |
| Di., 31.08.2021 | SV Babelsberg 03 - FC Carl Zeiss Jena | 0:2 |
| Mi., 01.09.2021 | FC Eilenburg - Berliner AK 07 | 0:1 |
| Mi., 01.09.2021 | VfB Germania Halberstadt - FSV Union Fürstenwalde | 2:1 |
| Mi., 01.09.2021 | FC Energie Cottbus - VSG Altglienicke | 0:3 |
| Mi., 01.09.2021 | SV Tasmania Berlin - VfB Auerbach | 3:1 |
| Mi., 13.10.2021 | Chemnitzer FC - 1. FC Lok Leipzig | 2:3 |
| Mi., 13.10.2021 | ZFC Meuselwitz - Tennis Borussia Berlin | 3:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 9 | 8-0-1 | 25:9 | 16 | 24 |
| 2. | |  | FSV 63 Luckenwalde | 9 | 6-2-1 | 21:6 | 15 | 20 |
| 3. | |  | Berliner AK 07 | 9 | 6-1-2 | 13:8 | 5 | 19 |
| 4. | |  | VSG Altglienicke | 8 | 5-2-1 | 16:9 | 7 | 17 |
| 5. |  |  | FC Carl Zeiss Jena | 8 | 5-1-2 | 16:6 | 10 | 16 |
| 6. | |  | VfB Germania Halberstadt | 8 | 5-0-3 | 18:11 | 7 | 15 |
| 7. |  |  | BSG Chemie Leipzig | 9 | 4-2-3 | 10:8 | 2 | 14 |
| 8. | |  | FC Energie Cottbus | 7 | 4-1-2 | 17:7 | 10 | 13 |
| 9. | |  | SV Babelsberg 03 | 8 | 4-1-3 | 8:8 | 0 | 13 |
| 10. | |  | Chemnitzer FC | 8 | 3-2-3 | 9:8 | 1 | 11 |
| 11. | |  | Hertha BSC Berlin II | 8 | 3-2-3 | 8:11 | -3 | 11 |
| 12. | |  | 1. FC Lok Leipzig | 6 | 3-1-2 | 12:6 | 6 | 10 |
| 13. | |  | SV Tasmania Berlin | 9 | 2-3-4 | 10:23 | -13 | 9 |
| 14. | |  | SV Lichtenberg 47 | 9 | 2-2-5 | 6:11 | -5 | 8 |
| 15. | |  | Tennis Borussia Berlin | 4 | 2-0-2 | 6:6 | 0 | 6 |
| 16. | |  | ZFC Meuselwitz | 8 | 2-0-6 | 8:14 | -6 | 6 |
| 17. | |  | FSV Optik Rathenow | 9 | 1-3-5 | 7:17 | -10 | 6 |
| 18. | |  | FSV Union Fürstenwalde | 9 | 1-2-6 | 12:26 | -14 | 5 |
| 19. | |  | FC Eilenburg | 9 | 0-3-6 | 5:14 | -9 | 3 |
| 20. | |  | VfB Auerbach | 8 | 1-0-7 | 8:27 | -19 | 3 |