| Sa., 08.11.1980 | 1. FC Magdeburg - 1. FC Lok Leipzig | 4:1 |
| Sa., 08.11.1980 | BSG Chemie Böhlen - BFC Dynamo | 2:2 |
| Sa., 08.11.1980 | FC Hansa Rostock - BSG Stahl Riesa | 6:2 |
| Sa., 08.11.1980 | FC Karl-Marx-Stadt - FC Carl Zeiss Jena | 3:2 |
| Sa., 08.11.1980 | FC Rot-Weiß Erfurt - HFC Chemie | 1:0 |
| Sa., 08.11.1980 | BSG Wismut Aue - BSG Sachsenring Zwickau | 2:1 |
| Sa., 08.11.1980 | SG Dynamo Dresden - FC Vorwärts Frankfurt/O. | 3:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | 1. FC Magdeburg | 10 | 8-1-1 | 26:8 | 18 | 17 - 3 |
| 2. | |  | SG Dynamo Dresden | 10 | 8-1-1 | 20:10 | 10 | 17 - 3 |
| 3. |  |  | BFC Dynamo | 10 | 7-2-1 | 31:8 | 23 | 16 - 4 |
| 4. |  |  | FC Carl Zeiss Jena | 10 | 7-0-3 | 26:15 | 11 | 14 - 6 |
| 5. | |  | 1. FC Lok Leipzig | 10 | 5-1-4 | 22:15 | 7 | 11 - 9 |
| 6. | |  | FC Hansa Rostock | 10 | 3-4-3 | 15:15 | 0 | 10 - 10 |
| 7. | |  | BSG Chemie Böhlen | 10 | 4-2-4 | 11:13 | -2 | 10 - 10 |
| 8. | |  | FC Vorwärts Frankfurt/O. | 10 | 3-3-4 | 20:22 | -2 | 9 - 11 |
| 9. | |  | FC Rot-Weiß Erfurt | 10 | 4-1-5 | 13:22 | -9 | 9 - 11 |
| 10. | |  | FC Karl-Marx-Stadt | 10 | 2-4-4 | 14:18 | -4 | 8 - 12 |
| 11. | |  | BSG Wismut Aue | 10 | 3-2-5 | 10:19 | -9 | 8 - 12 |
| 12. | |  | HFC Chemie | 10 | 3-0-7 | 15:21 | -6 | 6 - 14 |
| 13. | |  | BSG Stahl Riesa | 10 | 0-4-6 | 13:30 | -17 | 4 - 16 |
| 14. | |  | BSG Sachsenring Zwickau | 10 | 0-1-9 | 7:27 | -20 | 1 - 19 |