| Sa., 09.05.1981 | FC Vorwärts Frankfurt/O. - SG Dynamo Dresden | 3:0 |
| Sa., 09.05.1981 | 1. FC Lok Leipzig - 1. FC Magdeburg | 1:1 |
| Sa., 09.05.1981 | BSG Sachsenring Zwickau - BSG Wismut Aue | 3:2 |
| Sa., 09.05.1981 | HFC Chemie - FC Rot-Weiß Erfurt | 2:3 |
| Sa., 09.05.1981 | FC Carl Zeiss Jena - FC Karl-Marx-Stadt | 5:0 |
| Sa., 09.05.1981 | BSG Stahl Riesa - FC Hansa Rostock | 1:0 |
| Sa., 09.05.1981 | BFC Dynamo - BSG Chemie Böhlen | 2:0 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 23 | 15-5-3 | 67:26 | 41 | 35 - 11 |
| 2. |  |  | FC Carl Zeiss Jena | 23 | 14-4-5 | 50:25 | 25 | 32 - 14 |
| 3. |  |  | 1. FC Magdeburg | 23 | 14-4-5 | 52:30 | 22 | 32 - 14 |
| 4. | |  | SG Dynamo Dresden | 23 | 14-2-7 | 43:33 | 10 | 30 - 16 |
| 5. | |  | FC Vorwärts Frankfurt/O. | 23 | 11-5-7 | 49:34 | 15 | 27 - 19 |
| 6. | |  | FC Rot-Weiß Erfurt | 23 | 9-7-7 | 33:41 | -8 | 25 - 21 |
| 7. | |  | 1. FC Lok Leipzig | 23 | 10-4-9 | 39:28 | 11 | 24 - 22 |
| 8. | |  | HFC Chemie | 23 | 9-2-12 | 36:38 | -2 | 20 - 26 |
| 9. | |  | FC Hansa Rostock | 23 | 6-8-9 | 32:39 | -7 | 20 - 26 |
| 10. | |  | FC Karl-Marx-Stadt | 23 | 5-8-10 | 29:50 | -21 | 18 - 28 |
| 11. | |  | BSG Wismut Aue | 23 | 6-4-13 | 31:52 | -21 | 16 - 30 |
| 12. | |  | BSG Chemie Böhlen | 23 | 5-5-13 | 23:43 | -20 | 15 - 31 |
| 13. | |  | BSG Sachsenring Zwickau | 23 | 5-4-14 | 27:48 | -21 | 14 - 32 |
| 14. | |  | BSG Stahl Riesa | 23 | 5-4-14 | 34:58 | -24 | 14 - 32 |