| Fr., 03.12.2021 | Hertha BSC Berlin II - VfB Germania Halberstadt | 3:0 |
| Fr., 03.12.2021 | FC Carl Zeiss Jena - Berliner AK 07 | 2:0 |
| Fr., 03.12.2021 | SV Babelsberg 03 - SV Tasmania Berlin | 2:0 |
| Sa., 04.12.2021 | BSG Chemie Leipzig - FC Eilenburg | 2:1 |
| Sa., 04.12.2021 | FSV Optik Rathenow - VSG Altglienicke | 2:4 |
| Sa., 04.12.2021 | BFC Dynamo - 1. FC Lok Leipzig | 1:2 |
| So., 05.12.2021 | Tennis Borussia Berlin - Chemnitzer FC | 1:2 |
| So., 05.12.2021 | SV Lichtenberg 47 - ZFC Meuselwitz | 1:1 |
| So., 05.12.2021 | FSV 63 Luckenwalde - FC Energie Cottbus | 2:3 |
| So., 05.12.2021 | VfB Auerbach - FSV Union Fürstenwalde | abges. |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 20 | 14-3-3 | 47:19 | 28 | 45 |
| 2. |  |  | FC Energie Cottbus | 20 | 12-5-3 | 50:18 | 32 | 41 |
| 3. |  |  | Berliner AK 07 | 20 | 13-2-5 | 34:22 | 12 | 41 |
| 4. | |  | FC Carl Zeiss Jena | 20 | 12-4-4 | 39:19 | 20 | 40 |
| 5. | |  | 1. FC Lok Leipzig | 19 | 12-3-4 | 41:17 | 24 | 39 |
| 6. | |  | VSG Altglienicke | 20 | 11-5-4 | 37:23 | 14 | 38 |
| 7. | |  | Chemnitzer FC | 20 | 9-7-4 | 34:21 | 13 | 34 |
| 8. | |  | SV Babelsberg 03 | 20 | 10-4-6 | 29:22 | 7 | 34 |
| 9. | |  | Tennis Borussia Berlin | 20 | 9-3-8 | 31:28 | 3 | 30 |
| 10. | |  | FSV 63 Luckenwalde | 19 | 8-5-6 | 30:16 | 14 | 29 |
| 11. | |  | BSG Chemie Leipzig | 20 | 7-4-9 | 20:24 | -4 | 25 |
| 12. | |  | Hertha BSC Berlin II | 20 | 6-6-8 | 30:31 | -1 | 24 |
| 13. | |  | SV Lichtenberg 47 | 20 | 5-6-9 | 24:32 | -8 | 21 |
| 14. | |  | ZFC Meuselwitz | 20 | 6-3-11 | 22:31 | -9 | 21 |
| 15. | |  | VfB Germania Halberstadt | 20 | 5-4-11 | 24:39 | -15 | 19 |
| 16. | |  | SV Tasmania Berlin | 20 | 3-7-10 | 16:44 | -28 | 16 |
| 17. | |  | FSV Optik Rathenow | 20 | 2-8-10 | 22:38 | -16 | 14 |
| 18. | |  | FSV Union Fürstenwalde | 19 | 3-4-12 | 27:53 | -26 | 13 |
| 19. | |  | FC Eilenburg | 20 | 2-6-12 | 19:46 | -27 | 12 |
| 20. | |  | VfB Auerbach | 19 | 3-3-13 | 21:54 | -33 | 12 |