| Fr., 13.03.1981 | FC Carl Zeiss Jena - BSG Sachsenring Zwickau | 5:0 |
| Sa., 14.03.1981 | BFC Dynamo - FC Vorwärts Frankfurt/O. | 1:2 |
| Sa., 14.03.1981 | HFC Chemie - SG Dynamo Dresden | 4:2 |
| Sa., 14.03.1981 | BSG Stahl Riesa - 1. FC Lok Leipzig | 1:2 |
| Sa., 14.03.1981 | BSG Chemie Böhlen - 1. FC Magdeburg | 2:3 |
| Sa., 14.03.1981 | FC Hansa Rostock - BSG Wismut Aue | 4:1 |
| Sa., 14.03.1981 | FC Karl-Marx-Stadt - FC Rot-Weiß Erfurt | 1:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | 1. FC Magdeburg | 17 | 12-2-3 | 41:19 | 22 | 26 - 8 |
| 2. |  |  | BFC Dynamo | 17 | 11-3-3 | 44:16 | 28 | 25 - 9 |
| 3. | |  | FC Carl Zeiss Jena | 17 | 12-1-4 | 41:21 | 20 | 25 - 9 |
| 4. | |  | SG Dynamo Dresden | 17 | 11-2-4 | 34:24 | 10 | 24 - 10 |
| 5. |  |  | FC Vorwärts Frankfurt/O. | 17 | 7-4-6 | 36:29 | 7 | 18 - 16 |
| 6. | |  | 1. FC Lok Leipzig | 17 | 8-1-8 | 34:24 | 10 | 17 - 17 |
| 7. | |  | FC Hansa Rostock | 17 | 6-5-6 | 24:24 | 0 | 17 - 17 |
| 8. | |  | FC Rot-Weiß Erfurt | 17 | 6-4-7 | 22:34 | -12 | 16 - 18 |
| 9. | |  | HFC Chemie | 17 | 7-1-9 | 28:29 | -1 | 15 - 19 |
| 10. | |  | FC Karl-Marx-Stadt | 17 | 3-7-7 | 21:32 | -11 | 13 - 21 |
| 11. | |  | BSG Chemie Böhlen | 17 | 5-3-9 | 18:31 | -13 | 13 - 21 |
| 12. | |  | BSG Wismut Aue | 17 | 4-4-9 | 19:38 | -19 | 12 - 22 |
| 13. | |  | BSG Sachsenring Zwickau | 17 | 3-3-11 | 19:38 | -19 | 9 - 25 |
| 14. | |  | BSG Stahl Riesa | 17 | 2-4-11 | 22:44 | -22 | 8 - 26 |