| Sa., 13.11.2010 | VfB Auerbach - FSV Zwickau | 0:0 |
| Sa., 13.11.2010 | VfL Halle 96 - FSV Budissa Bautzen | 0:4 |
| Sa., 13.11.2010 | FC Rot-Weiß Erfurt II - VfB Germania Halberstadt | 1:4 |
| Sa., 13.11.2010 | FC Carl Zeiss Jena II - 1. FC Lok Leipzig | 3:1 |
| So., 14.11.2010 | Chemnitzer FC II - FC Erzgebirge Aue II | 3:2 |
| So., 14.11.2010 | FC Sachsen Leipzig - FSV Wacker 03 Gotha | 2:1 |
| So., 14.11.2010 | SG Dynamo Dresden II - FSV 63 Luckenwalde | 4:1 |
| So., 14.11.2010 | 1. FC Magdeburg II - SC Borea Dresden | 4:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | VfB Germania Halberstadt | 13 | 7-5-1 | 26:13 | 13 | 26 |
| 2. |  |  | FSV Budissa Bautzen | 13 | 7-4-2 | 21:9 | 12 | 25 |
| 3. |  |  | VfB Auerbach | 13 | 7-3-3 | 20:16 | 4 | 24 |
| 4. | |  | FC Rot-Weiß Erfurt II | 13 | 6-4-3 | 23:20 | 3 | 22 |
| 5. | |  | FC Sachsen Leipzig | 11 | 6-2-3 | 12:10 | 2 | 20 |
| 6. | |  | FC Erzgebirge Aue II | 12 | 5-3-4 | 18:11 | 7 | 18 |
| 7. | |  | FSV 63 Luckenwalde | 13 | 4-5-4 | 24:22 | 2 | 17 |
| 8. | |  | FC Carl Zeiss Jena II | 13 | 4-5-4 | 19:17 | 2 | 17 |
| 9. | |  | FSV Zwickau | 12 | 4-4-4 | 16:15 | 1 | 16 |
| 10. | |  | SG Dynamo Dresden II | 13 | 5-1-7 | 20:21 | -1 | 16 |
| 11. | |  | SC Borea Dresden | 12 | 4-4-4 | 15:18 | -3 | 16 |
| 12. | |  | FSV Wacker 03 Gotha | 13 | 4-3-6 | 21:23 | -2 | 15 |
| 13. | |  | 1. FC Magdeburg II | 13 | 3-3-7 | 15:29 | -14 | 12 |
| 14. | |  | VfL Halle 96 | 12 | 2-3-7 | 13:24 | -11 | 9 |
| 15. | |  | 1. FC Lok Leipzig | 10 | 1-5-4 | 13:18 | -5 | 8 |
| 16. | |  | Chemnitzer FC II | 12 | 2-2-8 | 16:26 | -10 | 8 |