| Fr., 11.02.2022 | SV Tasmania Berlin - BFC Dynamo | 0:3 |
| Sa., 12.02.2022 | Chemnitzer FC - Hertha BSC Berlin II | 2:0 |
| Sa., 12.02.2022 | FC Eilenburg - VfB Auerbach | 0:0 |
| Sa., 12.02.2022 | SV Lichtenberg 47 - BSG Chemie Leipzig | 2:1 |
| Sa., 12.02.2022 | 1. FC Lok Leipzig - FSV Union Fürstenwalde | 6:2 |
| Sa., 12.02.2022 | VfB Germania Halberstadt - FC Carl Zeiss Jena | 0:0 |
| So., 13.02.2022 | SV Babelsberg 03 - FSV 63 Luckenwalde | 2:1 |
| So., 13.02.2022 | VSG Altglienicke - Berliner AK 07 | 4:1 |
| So., 13.02.2022 | ZFC Meuselwitz - FSV Optik Rathenow | 4:1 |
| Mi., 30.03.2022 | FC Energie Cottbus - Tennis Borussia Berlin | 2:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 25 | 18-4-3 | 62:20 | 42 | 58 |
| 2. |  |  | 1. FC Lok Leipzig | 24 | 16-4-4 | 55:24 | 31 | 52 |
| 3. |  |  | FC Energie Cottbus | 24 | 14-6-4 | 55:20 | 35 | 48 |
| 4. | |  | FC Carl Zeiss Jena | 25 | 14-6-5 | 46:24 | 22 | 48 |
| 5. | |  | Berliner AK 07 | 25 | 15-3-7 | 40:30 | 10 | 48 |
| 6. | |  | Chemnitzer FC | 25 | 12-9-4 | 41:23 | 18 | 45 |
| 7. | |  | SV Babelsberg 03 | 25 | 13-5-7 | 36:26 | 10 | 44 |
| 8. | |  | VSG Altglienicke | 23 | 12-6-5 | 42:28 | 14 | 42 |
| 9. | |  | FSV 63 Luckenwalde | 25 | 10-6-9 | 40:25 | 15 | 36 |
| 10. | |  | BSG Chemie Leipzig | 25 | 10-5-10 | 27:27 | 0 | 35 |
| 11. | |  | Tennis Borussia Berlin | 23 | 10-4-9 | 36:31 | 5 | 34 |
| 12. | |  | Hertha BSC Berlin II | 25 | 9-6-10 | 40:40 | 0 | 33 |
| 13. | |  | SV Lichtenberg 47 | 25 | 7-7-11 | 31:37 | -6 | 28 |
| 14. | |  | ZFC Meuselwitz | 25 | 7-4-14 | 26:39 | -13 | 25 |
| 15. | |  | VfB Germania Halberstadt | 25 | 5-7-13 | 28:47 | -19 | 22 |
| 16. | |  | FC Eilenburg | 25 | 4-7-14 | 26:56 | -30 | 19 |
| 17. | |  | VfB Auerbach | 24 | 4-5-15 | 24:58 | -34 | 17 |
| 18. | |  | FSV Optik Rathenow | 25 | 2-10-13 | 26:51 | -25 | 16 |
| 19. | |  | SV Tasmania Berlin | 25 | 3-7-15 | 19:59 | -40 | 16 |
| 20. | |  | FSV Union Fürstenwalde | 24 | 3-5-16 | 33:68 | -35 | 14 |