| Di., 17.08.2021 | FC Carl Zeiss Jena - VfB Germania Halberstadt | 2:1 |
| Di., 17.08.2021 | FSV 63 Luckenwalde - SV Babelsberg 03 | 0:0 |
| Di., 17.08.2021 | BSG Chemie Leipzig - SV Lichtenberg 47 | 0:1 |
| Di., 17.08.2021 | FSV Union Fürstenwalde - 1. FC Lok Leipzig | 0:4 |
| Mi., 18.08.2021 | Hertha BSC Berlin II - Chemnitzer FC | 1:0 |
| Mi., 18.08.2021 | VfB Auerbach - FC Eilenburg | 2:1 |
| Mi., 18.08.2021 | FSV Optik Rathenow - ZFC Meuselwitz | 2:1 |
| Mi., 18.08.2021 | BFC Dynamo - SV Tasmania Berlin | 6:0 |
| Mi., 18.08.2021 | Berliner AK 07 - VSG Altglienicke | 0:2 |
| Mi., 06.10.2021 | Tennis Borussia Berlin - FC Energie Cottbus | 2:2 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 5 | 5-0-0 | 17:4 | 13 | 15 |
| 2. |  |  | FSV 63 Luckenwalde | 6 | 4-2-0 | 14:2 | 12 | 14 |
| 3. | |  | Berliner AK 07 | 6 | 4-1-1 | 10:4 | 6 | 13 |
| 4. | |  | VSG Altglienicke | 5 | 3-2-0 | 11:6 | 5 | 11 |
| 5. | |  | Chemnitzer FC | 6 | 3-1-2 | 8:5 | 3 | 10 |
| 6. | |  | BSG Chemie Leipzig | 6 | 3-1-2 | 7:5 | 2 | 10 |
| 7. | |  | VfB Germania Halberstadt | 5 | 3-0-2 | 9:7 | 2 | 9 |
| 8. | |  | Hertha BSC Berlin II | 5 | 2-2-1 | 3:5 | -2 | 8 |
| 9. | |  | FC Energie Cottbus | 4 | 2-1-1 | 8:3 | 5 | 7 |
| 10. | |  | 1. FC Lok Leipzig | 4 | 2-1-1 | 8:4 | 4 | 7 |
| 11. | |  | FC Carl Zeiss Jena | 5 | 2-1-2 | 6:5 | 1 | 7 |
| 12. | |  | SV Babelsberg 03 | 5 | 2-1-2 | 3:5 | -2 | 7 |
| 13. | |  | SV Lichtenberg 47 | 6 | 1-2-3 | 3:6 | -3 | 5 |
| 14. | |  | FSV Optik Rathenow | 6 | 1-2-3 | 4:9 | -5 | 5 |
| 15. | |  | SV Tasmania Berlin | 6 | 1-2-3 | 4:14 | -10 | 5 |
| 16. | |  | FSV Union Fürstenwalde | 6 | 1-1-4 | 9:17 | -8 | 4 |
| 17. | |  | Tennis Borussia Berlin | 3 | 1-0-2 | 4:6 | -2 | 3 |
| 18. | |  | ZFC Meuselwitz | 6 | 1-0-5 | 6:11 | -5 | 3 |
| 19. | |  | VfB Auerbach | 5 | 1-0-4 | 6:16 | -10 | 3 |
| 20. | |  | FC Eilenburg | 6 | 0-2-4 | 4:10 | -6 | 2 |