| So., 15.05.2022 | Chemnitzer FC - SV Tasmania Berlin | 5:0 |
| So., 15.05.2022 | Tennis Borussia Berlin - VfB Auerbach | 3:0 |
| So., 15.05.2022 | FSV Union Fürstenwalde - FC Carl Zeiss Jena | 1:0 |
| So., 15.05.2022 | Berliner AK 07 - FSV Optik Rathenow | 7:5 |
| So., 15.05.2022 | VSG Altglienicke - BFC Dynamo | 2:4 |
| So., 15.05.2022 | 1. FC Lok Leipzig - FSV 63 Luckenwalde | 3:1 |
| So., 15.05.2022 | FC Energie Cottbus - BSG Chemie Leipzig | 4:1 |
| So., 15.05.2022 | FC Eilenburg - Hertha BSC Berlin II | 2:3 |
| So., 15.05.2022 | VfB Germania Halberstadt - SV Lichtenberg 47 | 2:1 |
| So., 15.05.2022 | ZFC Meuselwitz - SV Babelsberg 03 | 1:1 |
| Sp. | S-U-N | Tore | Diff. | P | ||||
|---|---|---|---|---|---|---|---|---|
| 1. |  |  | BFC Dynamo | 38 | 25-7-6 | 84:32 | 52 | 82 |
| 2. | |  | FC Carl Zeiss Jena | 38 | 23-7-8 | 71:35 | 36 | 76 |
| 3. |  |  | FC Energie Cottbus | 38 | 21-11-6 | 85:35 | 50 | 74 |
| 4. |  |  | VSG Altglienicke | 38 | 21-9-8 | 80:47 | 33 | 72 |
| 5. | |  | Chemnitzer FC | 38 | 20-12-6 | 67:37 | 30 | 72 |
| 6. | |  | 1. FC Lok Leipzig | 38 | 21-8-9 | 71:42 | 29 | 71 |
| 7. | |  | Berliner AK 07 | 38 | 21-6-11 | 65:48 | 17 | 69 |
| 8. | |  | Hertha BSC Berlin II | 38 | 17-9-12 | 69:49 | 20 | 60 |
| 9. | |  | BSG Chemie Leipzig | 38 | 16-8-14 | 47:48 | -1 | 56 |
| 10. | |  | Tennis Borussia Berlin | 38 | 14-11-13 | 59:50 | 9 | 53 |
| 11. | |  | SV Babelsberg 03 | 38 | 14-11-13 | 46:42 | 4 | 53 |
| 12. | |  | FSV 63 Luckenwalde | 38 | 14-8-16 | 58:50 | 8 | 50 |
| 13. | |  | SV Lichtenberg 47 | 38 | 12-8-18 | 49:64 | -15 | 44 |
| 14. | |  | ZFC Meuselwitz | 38 | 11-8-19 | 42:54 | -12 | 41 |
| 15. | |  | VfB Germania Halberstadt | 38 | 11-8-19 | 48:68 | -20 | 41 |
| 16. | |  | FC Eilenburg | 38 | 8-9-21 | 41:79 | -38 | 33 |
| 17. | |  | FSV Union Fürstenwalde | 38 | 8-9-21 | 49:89 | -40 | 33 |
| 18. | |  | FSV Optik Rathenow | 38 | 5-15-18 | 48:81 | -33 | 30 |
| 19. | |  | VfB Auerbach | 38 | 5-8-25 | 45:95 | -50 | 23 |
| 20. | |  | SV Tasmania Berlin | 38 | 3-8-27 | 28:107 | -79 | 17 |